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    Rin2 Ras and Rab interactor 2 [ Mus musculus (house mouse) ]

    Gene ID: 74030, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rin2provided by MGI
    Official Full Name
    Ras and Rab interactor 2provided by MGI
    Primary source
    MGI:MGI:1921280
    See related
    Ensembl:ENSMUSG00000001768 AllianceGenome:MGI:1921280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RASSF4; 2010003K16Rik; 4632403N06Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of vasculogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 13.6), limb E14.5 (RPKM 10.8) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rin2 in Genome Data Viewer
    Location:
    2 G1; 2 71.25 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145613647..145729536)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145771727..145887616)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC039771 Neighboring gene predicted gene, 54120 Neighboring gene predicted gene, 34513 Neighboring gene STARR-seq mESC enhancer starr_05929 Neighboring gene predicted gene, 54121 Neighboring gene STARR-seq mESC enhancer starr_05932 Neighboring gene predicted gene, 39954 Neighboring gene STARR-seq mESC enhancer starr_05933 Neighboring gene STARR-positive B cell enhancer ABC_E8796 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    is_active_in endocytic vesicle  

    General protein information

    Preferred Names
    ras and Rab interactor 2
    Names
    ras interaction/interference protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001406508.1NP_001393437.1  ras and Rab interactor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672100
      UniProtKB/Swiss-Prot
      A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
    2. NM_001406509.1NP_001393438.1  ras and Rab interactor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672100
      UniProtKB/Swiss-Prot
      A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
      Related
      ENSMUSP00000105632.2, ENSMUST00000110005.8
    3. NM_001406510.1NP_001393439.1  ras and Rab interactor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672100
    4. NM_028724.5NP_083000.5  ras and Rab interactor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672100
      Consensus CDS
      CCDS50734.1
      UniProtKB/TrEMBL
      F8WGD2
      Related
      ENSMUSP00000092053.5, ENSMUST00000094480.11
      Conserved Domains (3) summary
      smart00167
      Location:614730
      VPS9; Domain present in VPS9
      cd10394
      Location:41140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:751841
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      145613647..145729536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500269.1XP_006500332.1  ras and Rab interactor 2 isoform X1

      See identical proteins and their annotated locations for XP_006500332.1

      UniProtKB/Swiss-Prot
      A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
      Conserved Domains (3) summary
      smart00167
      Location:659775
      VPS9; Domain present in VPS9
      cd10394
      Location:86185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:796886
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
    2. XM_036162625.1XP_036018518.1  ras and Rab interactor 2 isoform X2

      Conserved Domains (3) summary
      smart00167
      Location:606722
      VPS9; Domain present in VPS9
      cd10394
      Location:33132
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:743833
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
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