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    Ampd3 adenosine monophosphate deaminase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25095, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ampd3provided by RGD
    Official Full Name
    adenosine monophosphate deaminase 3provided by RGD
    Primary source
    RGD:2111
    See related
    EnsemblRapid:ENSRNOG00000018262 AllianceGenome:RGD:2111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables AMP deaminase activity. Predicted to be involved in erythrocyte homeostasis and purine ribonucleotide metabolic process. Predicted to act upstream of or within ADP metabolic process; ATP metabolic process; and energy homeostasis. Predicted to be active in cytosol. Orthologous to human AMPD3 (adenosine monophosphate deaminase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 67.7), Spleen (RPKM 46.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ampd3 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (174319526..174364605)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164884823..164929899)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (175585301..175630479)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 1, pseudogene 9 Neighboring gene uncharacterized LOC108349612 Neighboring gene uncharacterized LOC103691204 Neighboring gene ring finger protein 141 Neighboring gene lymphatic vessel endothelial hyaluronan receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables AMP deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in AMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in AMP catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in IMP salvage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    AMP deaminase 3
    Names
    Ampd
    NP_113732.2
    XP_006230072.1
    XP_006230073.1
    XP_006230074.1
    XP_006230075.1
    XP_006230076.1
    XP_006230077.1
    XP_038957285.1
    XP_038957300.1
    XP_063137312.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031544.2NP_113732.2  AMP deaminase 3

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O09178
      UniProtKB/TrEMBL
      A6I819, F1M7Q5
      Related
      ENSRNOP00000024933.5, ENSRNOT00000024933.7
      Conserved Domains (1) summary
      TIGR01429
      Location:181787
      AMP_deaminase; AMP deaminase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      174319526..174364605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230014.5XP_006230076.1  AMP deaminase 3 isoform X3

      See identical proteins and their annotated locations for XP_006230076.1

      UniProtKB/Swiss-Prot
      O09178
      UniProtKB/TrEMBL
      A6I821
      Conserved Domains (1) summary
      TIGR01429
      Location:145751
      AMP_deaminase; AMP deaminase
    2. XM_063281242.1XP_063137312.1  AMP deaminase 3 isoform X4

      UniProtKB/Swiss-Prot
      O09178
    3. XM_006230011.4XP_006230073.1  AMP deaminase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0N2, A6I820
      Related
      ENSRNOP00000084681.1, ENSRNOT00000112866.2
      Conserved Domains (2) summary
      PLN03055
      Location:197761
      PLN03055; AMP deaminase; Provisional
      TIGR01429
      Location:154760
      AMP_deaminase; AMP deaminase
    4. XM_006230015.5XP_006230077.1  AMP deaminase 3 isoform X3

      See identical proteins and their annotated locations for XP_006230077.1

      UniProtKB/Swiss-Prot
      O09178
      UniProtKB/TrEMBL
      A6I821
      Conserved Domains (1) summary
      TIGR01429
      Location:145751
      AMP_deaminase; AMP deaminase
    5. XM_006230013.5XP_006230075.1  AMP deaminase 3 isoform X3

      See identical proteins and their annotated locations for XP_006230075.1

      UniProtKB/Swiss-Prot
      O09178
      UniProtKB/TrEMBL
      A6I821
      Conserved Domains (1) summary
      TIGR01429
      Location:145751
      AMP_deaminase; AMP deaminase
    6. XM_006230012.5XP_006230074.1  AMP deaminase 3 isoform X3

      See identical proteins and their annotated locations for XP_006230074.1

      UniProtKB/Swiss-Prot
      O09178
      UniProtKB/TrEMBL
      A6I821
      Conserved Domains (1) summary
      TIGR01429
      Location:145751
      AMP_deaminase; AMP deaminase
    7. XM_006230010.5XP_006230072.1  AMP deaminase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A9F8, A6I820
      Related
      ENSRNOP00000088165.1, ENSRNOT00000106719.2
      Conserved Domains (2) summary
      PLN03055
      Location:212776
      PLN03055; AMP deaminase; Provisional
      TIGR01429
      Location:169775
      AMP_deaminase; AMP deaminase
    8. XM_039101357.2XP_038957285.1  AMP deaminase 3 isoform X3

      UniProtKB/Swiss-Prot
      O09178
      UniProtKB/TrEMBL
      A6I821
      Related
      ENSRNOP00000109764.1, ENSRNOT00000135140.1
      Conserved Domains (1) summary
      TIGR01429
      Location:145751
      AMP_deaminase; AMP deaminase
    9. XM_039101372.2XP_038957300.1  AMP deaminase 3 isoform X5

      Conserved Domains (1) summary
      cl00281
      Location:1430
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...