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    Pth parathyroid hormone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24694, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pthprovided by RGD
    Official Full Name
    parathyroid hormoneprovided by RGD
    Primary source
    RGD:3440
    See related
    EnsemblRapid:ENSRNOG00000014318 AllianceGenome:RGD:3440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pth1; Pthr1; PTH-(1-84)
    Summary
    Enables hormone activity; peptide hormone receptor binding activity; and type 1 parathyroid hormone receptor binding activity. Involved in several processes, including Rho protein signal transduction; negative regulation of chondrocyte differentiation; and regulation of bone mineralization. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and intracellular calcium ion homeostasis. Located in extracellular space. Used to study several diseases, including chronic kidney disease; hyperphosphatemia; nephrocalcinosis; osteoporosis; and secondary hyperparathyroidism. Biomarker of autosomal dominant hypocalcemia; kidney failure (multiple); osteoporosis; and secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 25.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pth in Genome Data Viewer
    Location:
    1q33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (176942901..176946034, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (167508121..167511530, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (178215829..178218761, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BTB domain containing 10 Neighboring gene uncharacterized LOC134484822 Neighboring gene RNA, U6 small nuclear 26 Neighboring gene enolase 1, pseudogene 9 Neighboring gene cytochrome c, somatic-like Neighboring gene fatty acyl CoA reductase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables parathyroid hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables parathyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide hormone receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables receptor ligand activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables type 1 parathyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables type 1 parathyroid hormone receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables type 1 parathyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process in bone marrow cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bone mineralization involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phosphate ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of D-glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of D-glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of bone mineralization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of osteoclast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fibroblast growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to parathyroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    parathyroid hormone
    Names
    hypothalamic parathyroid hormone
    parathyrin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017044.1NP_058740.1  parathyroid hormone precursor

      See identical proteins and their annotated locations for NP_058740.1

      Status: PROVISIONAL

      Source sequence(s)
      X05721
      UniProtKB/Swiss-Prot
      P04089, Q63473
      UniProtKB/TrEMBL
      A6I885, Q80WZ2
      Related
      ENSRNOP00000019199.1, ENSRNOT00000019199.4
      Conserved Domains (1) summary
      smart00087
      Location:3065
      PTH; Parathyroid hormone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      176942901..176946034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100789.2XP_038956717.1  parathyroid hormone isoform X1

      UniProtKB/Swiss-Prot
      P04089, Q63473
      UniProtKB/TrEMBL
      A6I885, Q80WZ2
      Conserved Domains (1) summary
      smart00087
      Location:3065
      PTH; Parathyroid hormone