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    Rab38 RAB38, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252916, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rab38provided by RGD
    Official Full Name
    RAB38, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:628752
    See related
    EnsemblRapid:ENSRNOG00000016769 AllianceGenome:RGD:628752
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ruby
    Summary
    Enables GTP binding activity. Involved in platelet dense granule organization; positive regulation of biosynthetic process; and positive regulation of protein localization to cell periphery. Located in cell body; melanosome; and perinuclear region of cytoplasm. Used to study Hermansky-Pudlak syndrome; platelet storage pool deficiency; and proteinuria. Orthologous to human RAB38 (RAB38, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 169.1), Lung (RPKM 154.8) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rab38 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (151595153..151675492)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (142182566..142262923)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (152072716..152153449)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene cathepsin C Neighboring gene phosphoglycerate kinase 1, pseudogene 7 Neighboring gene ribosomal protein S19, pseudogene 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AP-1 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables AP-2 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables AP-3 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables BLOC-2 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GDP binding IC
    Inferred by Curator
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IC
    Inferred by Curator
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in early endosome lumen ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-38
    Names
    Rab38, member of RAS oncogene family
    red eyed dilution
    ruby or red eyed dilution
    small GTP binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145774.3NP_665717.1  ras-related protein Rab-38

      See identical proteins and their annotated locations for NP_665717.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I5Z5, F7F483, Q63483
      Related
      ENSRNOP00000022538.3, ENSRNOT00000022538.7
      Conserved Domains (1) summary
      cd04107
      Location:10208
      Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      151595153..151675492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)