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    Rps6 ribosomal protein S6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29304, updated on 27-Nov-2024

    Summary

    Symbol
    Rps6provided by RGD
    Full Name
    ribosomal protein S6provided by RGD
    Primary source
    RGD:3602
    See related
    EnsemblRapid:ENSRNOG00000049025 AllianceGenome:RGD:3602
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables mRNA binding activity. A structural constituent of ribosome. Involved in several processes, including cellular response to ethanol; negative regulation of bicellular tight junction assembly; and ribosomal small subunit assembly. Part of cytosolic small ribosomal subunit. Is active in GABA-ergic synapse; presynapse; and ribosome. Used to study transient cerebral ischemia. Biomarker of vascular dementia. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 8667.2), Thymus (RPKM 8100.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rps6 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106417680..106420540, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101371716..101374576, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (105197821..105200681, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547623 Neighboring gene uncharacterized LOC134486947 Neighboring gene DENN domain containing 4C Neighboring gene alkaline ceramidase 2 Neighboring gene uncharacterized LOC134486948 Neighboring gene small ribosomal subunit protein uS10-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation-induced cell death of T cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastrulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within mammalian oogenesis stage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of bicellular tight junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    small ribosomal subunit protein eS6
    Names
    40S ribosomal protein S6
    40S ribosomal protein S6-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017160.1NP_058856.1  small ribosomal subunit protein eS6

      See identical proteins and their annotated locations for NP_058856.1

      Status: PROVISIONAL

      Source sequence(s)
      M29358
      UniProtKB/Swiss-Prot
      P62755
      UniProtKB/TrEMBL
      A6KRB6, M0RD75
      Related
      ENSRNOP00000067572.2, ENSRNOT00000073270.4
      Conserved Domains (1) summary
      cl00931
      Location:1215
      Ribosomal_S6e; Ribosomal protein S6e

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      106417680..106420540 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)