Adcy4 adenylate cyclase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy4provided by MGI
Official Full Name: adenylate cyclase 4provided by MGI
Primary source: MGI:MGI:99674
See related: Ensembl:ENSMUSG00000022220 AllianceGenome:MGI:99674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA4004
Summary: Predicted to enable G-protein beta/gamma-subunit complex binding activity; adenylate cyclase activity; and protein kinase C binding activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in dendrite. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to human ADCY4 (adenylate cyclase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 35.4), subcutaneous fat pad adult (RPKM 10.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56006513..56021552, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55769056..55784095, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.
Title: In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.
SF1 and SP1 contribute to Adcy4 promoter activity via interation with conserved region situated 19 bp upstream of the major transcription start site.
Title: Contributions of specificity protein-1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells.
Adcy4 deficiency is a hallmark of the forskolin-resistant phenotype of the adrenocortical tumor mutants studied and Adcy4 is an important target of forskolin action in the Y1 adrenal cell line.
Title: Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adcy4 (e-PCR), detects polymorphism
- UniSTS:496003

NoName (e-PCR)
- UniSTS:237189

AW107945 (e-PCR)
- UniSTS:180664

Adcy4 (e-PCR), detects polymorphism
- UniSTS:141031

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cAMP biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate cyclase type 4

Names: ATP pyrophosphate-lyase 4; adenylate cyclase type IV; adenylyl cyclase 4

NP_001348533.1

EC 4.6.1.1

NP_536683.1

EC 4.6.1.1

XP_006518387.1

EC 4.6.1.1

XP_006518388.1

EC 4.6.1.1

XP_006518389.1

EC 4.6.1.1

XP_036014230.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361604.1 → NP_001348533.1 adenylate cyclase type 4

Status: VALIDATED

Source sequence(s)

AC098877, AK141767, BY346402

Consensus CDS

CCDS27130.1

UniProtKB/Swiss-Prot

Q91WF3

UniProtKB/TrEMBL

Q3UR61

Related

ENSMUSP00000130530.2, ENSMUST00000170223.9

Conserved Domains (3) summary

pfam00211
Location:866 → 1065

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:115 → 246

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:479 → 580

DUF1053; Domain of Unknown Function (DUF1053)
NM_080435.2 → NP_536683.1 adenylate cyclase type 4

See identical proteins and their annotated locations for NP_536683.1

Status: VALIDATED

Source sequence(s)

AC098877, AK141767, AK161880, BY346402

Consensus CDS

CCDS27130.1

UniProtKB/Swiss-Prot

Q91WF3

UniProtKB/TrEMBL

Q3UR61

Related

ENSMUSP00000002398.8, ENSMUST00000002398.9

Conserved Domains (3) summary

pfam00211
Location:866 → 1065

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:115 → 246

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:479 → 580

DUF1053; Domain of Unknown Function (DUF1053)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

56006513..56021552 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518324.1 → XP_006518387.1 adenylate cyclase type 4 isoform X1

See identical proteins and their annotated locations for XP_006518387.1

UniProtKB/Swiss-Prot

Q91WF3

UniProtKB/TrEMBL

Q3UR61

Conserved Domains (3) summary

pfam00211
Location:866 → 1065

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:115 → 246

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:479 → 580

DUF1053; Domain of Unknown Function (DUF1053)
XM_036158337.1 → XP_036014230.1 adenylate cyclase type 4 isoform X4

Conserved Domains (3) summary

pfam00211
Location:525 → 724

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:138 → 239

DUF1053; Domain of Unknown Function (DUF1053)

cl11967
Location:15 → 77

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
XM_006518326.3 → XP_006518389.1 adenylate cyclase type 4 isoform X3

Conserved Domains (3) summary

pfam00211
Location:552 → 751

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:165 → 266

DUF1053; Domain of Unknown Function (DUF1053)

cl11967
Location:2 → 104

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
XM_006518325.3 → XP_006518388.1 adenylate cyclase type 4 isoform X2

UniProtKB/TrEMBL

Q3TSQ4, Q3UR61

Conserved Domains (4) summary

pfam00211
Location:264 → 418

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:115 → 246

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:479 → 580

DUF1053; Domain of Unknown Function (DUF1053)

cl11967
Location:866 → 939

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases