U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rpp40 ribonuclease P 40 subunit [ Mus musculus (house mouse) ]

    Gene ID: 208366, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rpp40provided by MGI
    Official Full Name
    ribonuclease P 40 subunitprovided by MGI
    Primary source
    MGI:MGI:1346084
    See related
    Ensembl:ENSMUSG00000021418 AllianceGenome:MGI:1346084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnasep1; D8Bwg1265e
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease MRP activity and ribonuclease P activity. Predicted to be involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP40 (ribonuclease P/MRP subunit p40). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 1.8), CNS E11.5 (RPKM 1.7) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rpp40 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (36080685..36095548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (35895104..35911565, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34172 Neighboring gene STARR-seq mESC enhancer starr_34173 Neighboring gene predicted gene, 22674 Neighboring gene STARR-seq mESC enhancer starr_34176 Neighboring gene STARR-seq mESC enhancer starr_34177 Neighboring gene predicted gene, 22126 Neighboring gene STARR-seq mESC enhancer starr_34179 Neighboring gene STARR-positive B cell enhancer ABC_E10788 Neighboring gene chromodomain protein, Y chromosome-like Neighboring gene STARR-seq mESC enhancer starr_34180 Neighboring gene STARR-seq mESC enhancer starr_34183 Neighboring gene STARR-seq mESC enhancer starr_34184 Neighboring gene protein phosphatase 1, regulatory subunit 3G Neighboring gene predicted gene, 30127 Neighboring gene transmembrane p24 trafficking protein 10, pseudogene Neighboring gene predicted gene, 18132 Neighboring gene LYR motif containing 4

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P. Jarrous N, et al. RNA, 1998 Apr. PMID 9630247, Free PMC Article
    2. Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Durkin ME, et al. Gene, 2002 Apr 17. PMID 12034501
    3. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC25944

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ribonuclease MRP activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease P RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    contributes_to ribonuclease P activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA 5'-leader removal ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of multimeric ribonuclease P complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nucleolar ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ribonuclease P protein subunit p40
    Names
    RNaseP protein p40
    ribonuclease P 40kDa subunit
    ribonuclease P1
    NP_001413309.1
    NP_001413310.1
    NP_001413311.1
    NP_001413312.1
    NP_001413313.1
    NP_001413314.1
    NP_001413315.1
    NP_666050.3
    XP_006516694.1
    XP_011242604.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426380.1 → NP_001413309.1  ribonuclease P protein subunit p40 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209

    2. NM_001426381.1 → NP_001413310.1  ribonuclease P protein subunit p40 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209

    3. NM_001426382.1 → NP_001413311.1  ribonuclease P protein subunit p40 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209

    4. NM_001426383.1 → NP_001413312.1  ribonuclease P protein subunit p40 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209

    5. NM_001426384.1 → NP_001413313.1  ribonuclease P protein subunit p40 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209
      UniProtKB/TrEMBL
      G3UYU5
      Related
      ENSMUSP00000134228.2, ENSMUST00000174230.2

    6. NM_001426385.1 → NP_001413314.1  ribonuclease P protein subunit p40 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209

    7. NM_001426386.1 → NP_001413315.1  ribonuclease P protein subunit p40 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209

    8. NM_145938.5 → NP_666050.3  ribonuclease P protein subunit p40 isoform 1

      See identical proteins and their annotated locations for NP_666050.3

      Status: VALIDATED

      Source sequence(s)
      AC134860, AC159209
      Consensus CDS
      CCDS26451.2
      UniProtKB/Swiss-Prot
      Q8BX66, Q8R1F9
      Related
      ENSMUSP00000130290.3, ENSMUST00000171686.9
      Conserved Domains (1) summary
      pfam08584
      Location:75 → 343
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      36080685..36095548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244302.1 → XP_011242604.1  ribonuclease P protein subunit p40 isoform X2

      See identical proteins and their annotated locations for XP_011242604.1

      Conserved Domains (1) summary
      pfam08584
      Location:15 → 282
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit

    2. XM_006516631.4 → XP_006516694.1  ribonuclease P protein subunit p40 isoform X1

      Conserved Domains (1) summary
      pfam08584
      Location:41 → 308
      Ribonuc_P_40; Ribonuclease P 40kDa (Rpp40) subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1F9.2 GenPept UniProtKB/Swiss-Prot:Q8R1F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous