Asb9 ankyrin repeat and SOCS box-containing 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asb9provided by MGI
Official Full Name: ankyrin repeat and SOCS box-containing 9provided by MGI
Primary source: MGI:MGI:1916549
See related: Ensembl:ENSMUSG00000031384 AllianceGenome:MGI:1916549
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700011M07Rik
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in mitochondrion. Predicted to be part of Cul5-RING ubiquitin ligase complex. Is expressed in limb. Orthologous to human ASB9 (ankyrin repeat and SOCS box containing 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 58.3) See more
Orthologs: human all
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Genomic context

Location:: X F5; X 76.73 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (163280899..163322748)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (164497903..164539752)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mAsb-9 could be a specific marker of active spermatogenesis and would be useful for studies of male germ cell development.
Title: Expression of murine Asb-9 during mouse spermatogenesis.
creatine kinase B (CKB) interacts with Asb-9 in a specific, SOCS box-independent manner
Title: Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 9

Names: ASB-9; ankyrin repeat and SOCS box-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027027.2 → NP_081303.1 ankyrin repeat and SOCS box protein 9

See identical proteins and their annotated locations for NP_081303.1

Status: VALIDATED

Source sequence(s)

AK005878

Consensus CDS

CCDS30524.1

UniProtKB/Swiss-Prot

Q6GT43, Q91ZT8, Q9DAF7

Related

ENSMUSP00000033756.3, ENSMUST00000033756.3

Conserved Domains (5) summary

cd00204
Location:59 → 183

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:69 → 159

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:33 → 85

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:31 → 62

ANK; ANK repeat [structural motif]

cl02533
Location:249 → 290

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...