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    Zscan25 zinc finger and SCAN domain containing 25 [ Mus musculus (house mouse) ]

    Gene ID: 666311, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zscan25provided by MGI
    Official Full Name
    zinc finger and SCAN domain containing 25provided by MGI
    Primary source
    MGI:MGI:3647079
    See related
    Ensembl:ENSMUSG00000070420 AllianceGenome:MGI:3647079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp498; EG666311
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human ZSCAN25 (zinc finger and SCAN domain containing 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 9.9), thymus adult (RPKM 8.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zscan25 in Genome Data Viewer
    Location:
    5 G2; 5 85.17 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145217261..145229050)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145280451..145292240)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene zinc finger protein 655 Neighboring gene predicted gene 9710 Neighboring gene STARR-positive B cell enhancer ABC_E6398 Neighboring gene STARR-seq mESC enhancer starr_14828 Neighboring gene STARR-seq mESC enhancer starr_14829 Neighboring gene STARR-seq mESC enhancer starr_14831 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 57 Neighboring gene sperm motility kinase 3A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 25
    Names
    zinc finger protein 498

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081431.2 → NP_001074900.1  zinc finger and SCAN domain-containing protein 25 isoform 1

      See identical proteins and their annotated locations for NP_001074900.1

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Consensus CDS
      CCDS39387.1
      UniProtKB/TrEMBL
      B2RX31
      Related
      ENSMUSP00000091664.4, ENSMUST00000094116.5
      Conserved Domains (4) summary
      COG5048
      Location:338 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:404 → 424
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:38 → 120
      SCAN; SCAN domain
      cl02581
      Location:230 → 258
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. NM_001384204.1 → NP_001371133.1  zinc finger and SCAN domain-containing protein 25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      COG5048
      Location:272 → 465
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:38 → 120
      SCAN; SCAN domain
      cl02581
      Location:164 → 192
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. NM_001384205.1 → NP_001371134.1  zinc finger and SCAN domain-containing protein 25 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      COG5048
      Location:123 → 288
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:189 → 209
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:284 → 309
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:15 → 43
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. NM_001384206.1 → NP_001371135.1  zinc finger and SCAN domain-containing protein 25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127411
      UniProtKB/TrEMBL
      B2RX31
      Conserved Domains (4) summary
      COG5048
      Location:338 → 531
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:404 → 424
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:38 → 120
      SCAN; SCAN domain
      cl02581
      Location:230 → 258
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. NM_001384207.1 → NP_001371136.1  zinc finger and SCAN domain-containing protein 25 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      COG5048
      Location:123 → 288
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:189 → 209
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:284 → 309
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:15 → 43
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145217261..145229050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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