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    Cep350 centrosomal protein 350 [ Mus musculus (house mouse) ]

    Gene ID: 74081, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cep350provided by MGI
    Official Full Name
    centrosomal protein 350provided by MGI
    Primary source
    MGI:MGI:1921331
    See related
    Ensembl:ENSMUSG00000033671 AllianceGenome:MGI:1921331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933409L06Rik; 6430546F08Rik
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be located in centriole. Predicted to be active in centrosome. Is expressed in brain; lung; and testis. Orthologous to human CEP350 (centrosomal protein 350). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.6), CNS E18 (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep350 in Genome Data Viewer
    Location:
    1 G3; 1 67.64 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155720710..155848976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155844964..155973270, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02727 Neighboring gene LIM homeobox protein 4 Neighboring gene quiescin Q6 sulfhydryl oxidase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157659814-157660115 Neighboring gene predicted gene, 36934 Neighboring gene predicted gene, 51652 Neighboring gene STARR-positive B cell enhancer ABC_E9186 Neighboring gene predicted gene, 23744 Neighboring gene predicted gene, 53631 Neighboring gene torsin A interacting protein 1 Neighboring gene predicted gene, 51653

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Weidemann M, et al. Development, 2016 Dec 15. PMID 27965440
    2. EB1 is required for primary cilia assembly in fibroblasts. Schrøder JM, et al. Curr Biol, 2007 Jul 3. PMID 17600711
    3. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Licatalosi DD, et al. Genes Dev, 2012 Jul 15. PMID 22802532, Free PMC Article
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107324

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosome-associated protein 350

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039184.2 → NP_001034273.1  centrosome-associated protein 350

      Status: VALIDATED

      Source sequence(s)
      AC120391, AC121314
      Consensus CDS
      CCDS48400.1
      UniProtKB/Swiss-Prot
      A0A1D5RMJ4, D3YTP2, E9Q309, Q6A062, Q8BXM7
      Related
      ENSMUSP00000120085.2, ENSMUST00000138762.8
      Conserved Domains (3) summary
      pfam01302
      Location:2486 → 2550
      CAP_GLY; CAP-Gly domain
      cl25632
      Location:1317 → 1439
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      cl26511
      Location:1563 → 2290
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      155720710..155848976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529903.5 → XP_006529966.1  centrosome-associated protein 350 isoform X3

      Conserved Domains (5) summary
      PTZ00121
      Location:1335 → 1813
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:2094 → 2374
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:2530 → 2807
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:1889 → 2150
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2530 → 2594
      CAP_GLY; CAP-Gly domain

    2. XM_006529907.5 → XP_006529970.1  centrosome-associated protein 350 isoform X9

      Conserved Domains (4) summary
      TIGR01843
      Location:1318 → 1440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:1564 → 2291
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:2487 → 2764
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:2487 → 2551
      CAP_GLY; CAP-Gly domain

    3. XM_030243199.2 → XP_030099059.1  centrosome-associated protein 350 isoform X5

      Conserved Domains (5) summary
      PTZ00121
      Location:1365 → 1812
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:2092 → 2372
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:2528 → 2805
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:1887 → 2148
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2528 → 2592
      CAP_GLY; CAP-Gly domain

    4. XM_006529906.5 → XP_006529969.1  centrosome-associated protein 350 isoform X8

      Conserved Domains (4) summary
      TIGR01843
      Location:1318 → 1440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:1565 → 2292
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:2488 → 2765
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:2488 → 2552
      CAP_GLY; CAP-Gly domain

    5. XM_006529904.5 → XP_006529967.1  centrosome-associated protein 350 isoform X4

      Conserved Domains (7) summary
      TIGR01843
      Location:1318 → 1440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:1486 → 1813
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:2093 → 2373
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:2529 → 2806
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PRK12704
      Location:1677 → 1779
      PRK12704; phosphodiesterase; Provisional
      PTZ00108
      Location:1888 → 2149
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2529 → 2593
      CAP_GLY; CAP-Gly domain

    6. XM_030243200.2 → XP_030099060.1  centrosome-associated protein 350 isoform X7

      Conserved Domains (4) summary
      TIGR01843
      Location:1318 → 1440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:1566 → 2293
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:2489 → 2766
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam01302
      Location:2489 → 2553
      CAP_GLY; CAP-Gly domain

    7. XM_006529902.5 → XP_006529965.1  centrosome-associated protein 350 isoform X2

      Conserved Domains (7) summary
      TIGR01843
      Location:1318 → 1440
      type_I_hlyD; type I secretion membrane fusion protein, HlyD family
      PTZ00121
      Location:1345 → 1814
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:2094 → 2374
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:2530 → 2807
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PRK12704
      Location:1678 → 1780
      PRK12704; phosphodiesterase; Provisional
      PTZ00108
      Location:1889 → 2150
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2530 → 2594
      CAP_GLY; CAP-Gly domain

    8. XM_006529905.5 → XP_006529968.1  centrosome-associated protein 350 isoform X6

      Conserved Domains (4) summary
      PTZ00121
      Location:1336 → 1981
      PTZ00121; MAEBL; Provisional
      COG5244
      Location:2490 → 2767
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      pfam02463
      Location:1681 → 2324
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam01302
      Location:2490 → 2554
      CAP_GLY; CAP-Gly domain

    9. XM_006529900.5 → XP_006529963.1  centrosome-associated protein 350 isoform X1

      Conserved Domains (5) summary
      PTZ00121
      Location:1336 → 1814
      PTZ00121; MAEBL; Provisional
      COG5022
      Location:2095 → 2375
      COG5022; Myosin heavy chain [General function prediction only]
      COG5244
      Location:2531 → 2808
      NIP100; Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]
      PTZ00108
      Location:1890 → 2151
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2531 → 2595
      CAP_GLY; CAP-Gly domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q309.1 GenPept UniProtKB/Swiss-Prot:E9Q309

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