Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnc4provided by MGI
Official Full Name: potassium voltage gated channel, Shaw-related subfamily, member 4provided by MGI
Primary source: MGI:MGI:96670
See related: Ensembl:ENSMUSG00000027895 AllianceGenome:MGI:96670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv3.4; Kcr2-4; KSHIIIC
Summary: Predicted to enable delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Acts upstream of or within regulation of neurotransmitter secretion. Located in axon terminus and neuromuscular junction. Is expressed in central nervous system; olfactory epithelium; and peripheral nervous system ganglion. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 11.1), cerebellum adult (RPKM 9.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.83 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107345614..107367617, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107438298..107460287, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice.
Title: Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice.
Kv3 channels, which drive AP repolarization, rapidly inactivated upon incorporation of Kv3.4 subunits.
Title: Rapid State-Dependent Alteration in K(v)3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.
KV3.4 channel subunits are precociously upregulated in cultured astrocytes exposed to Ab oligomers.
Title: The expression and activity of K(V)3.4 channel subunits are precociously upregulated in astrocytes exposed to Aβ oligomers and in astrocytes of Alzheimer's disease Tg2576 mice.
Although all Kv3 transcripts are significantly expressed in embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins were present, suggesting a novel role for Kv3 channels at this developmental stage.
Title: Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in calyx of Held	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-gated potassium channel KCNC4; potassium voltage-gated channel subfamily C member 4

Names: voltage-gated potassium channel subunit Kv3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356447.2 → NP_001343376.1 voltage-gated potassium channel KCNC4 isoform 1

Status: VALIDATED

Source sequence(s)

AC124727

Conserved Domains (3) summary

pfam11404
Location:1 → 29

Potassium_chann; Potassium voltage-gated channel

cd18415
Location:35 → 162

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:229 → 487

Ion_trans; Ion transport protein
NM_145922.4 → NP_666034.1 voltage-gated potassium channel KCNC4 isoform 2

See identical proteins and their annotated locations for NP_666034.1

Status: VALIDATED

Source sequence(s)

AC124727

Consensus CDS

CCDS17738.1

UniProtKB/Swiss-Prot

Q8R1C0

Related

ENSMUSP00000009617.9, ENSMUST00000009617.10

Conserved Domains (3) summary

pfam11404
Location:1 → 29

Potassium_chann; Potassium voltage-gated channel

cd18415
Location:35 → 162

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:229 → 487

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

107345614..107367617 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502475.5 → XP_006502538.1 potassium voltage-gated channel subfamily C member 4 isoform X1

UniProtKB/TrEMBL

A0A571BG98

Related

ENSMUSP00000158751.2, ENSMUST00000238670.2

Conserved Domains (3) summary

pfam11404
Location:1 → 29

Potassium_chann; Potassium voltage-gated channel

cd18415
Location:35 → 162

BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4

pfam00520
Location:229 → 487

Ion_trans; Ion transport protein