Usp12 ubiquitin specific peptidase 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp12provided by MGI
Official Full Name: ubiquitin specific peptidase 12provided by MGI
Primary source: MGI:MGI:1270128
See related: Ensembl:ENSMUSG00000029640 AllianceGenome:MGI:1270128
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ubh1
Summary: Enables deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; gonad; metanephros; and retina layer. Orthologous to human USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 11.4), large intestine adult (RPKM 10.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G3; 5 86.0 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (146671619..146731817, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (146734809..146794956, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP12 promotes breast cancer angiogenesis by maintaining midkine stability.
Title: USP12 promotes breast cancer angiogenesis by maintaining midkine stability.
USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10.
Title: USP12 promotes CD4(+) T cell responses through deubiquitinating and stabilizing BCL10.
De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
Title: De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
cellular USP12 interacts with the HAT domain of CBP and inhibits CBP's acetyltransferase activity
Title: USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity.
Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
Title: Deubiquitinase USP12 promotes LPS induced macrophage responses through inhibition of IκBα.
Product has deubiquitinating enzyme activity and sequence analysis showed 98.3% amino acid identity with human UBH1.
Title: Molecular cloning and complete cDNA sequence of UBH1 in mouse testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 12

Names: deubiquitinating enzyme 12; ubiquitin specific protease 12; ubiquitin thioesterase 12; ubiquitin thiolesterase 12; ubiquitin-hydrolyzing enzyme 1; ubiquitin-specific-processing protease 12

NP_035799.1

EC 3.4.19.12

XP_006504882.1

EC 3.4.19.12

XP_030110225.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011669.3 → NP_035799.1 ubiquitin carboxyl-terminal hydrolase 12

See identical proteins and their annotated locations for NP_035799.1

Status: PROVISIONAL

Source sequence(s)

AC124828, AC127589

Consensus CDS

CCDS39395.1

UniProtKB/Swiss-Prot

Q790B0, Q7TNV4, Q80Y43, Q8CBN8, Q9D9M2

Related

ENSMUSP00000082754.6, ENSMUST00000085614.6

Conserved Domains (2) summary

cd02663
Location:40 → 367

Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:38 → 366

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

146671619..146731817 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254365.2 → XP_030110225.1 ubiquitin carboxyl-terminal hydrolase 12 isoform X1

Related

ENSMUST00000138202.8

Conserved Domains (1) summary

cd02663
Location:1 → 247

Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_006504819.4 → XP_006504882.1 ubiquitin carboxyl-terminal hydrolase 12 isoform X2

Conserved Domains (1) summary

cl02553
Location:40 → 194

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...