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    Hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 232989, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnpul1provided by MGI
    Official Full Name
    heterogeneous nuclear ribonucleoprotein U-like 1provided by MGI
    Primary source
    MGI:MGI:2443517
    See related
    Ensembl:ENSMUSG00000040725 AllianceGenome:MGI:2443517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E1BAP5; E1B-AP5; Hnrnpul; Hnrpul1; E130317O14Rik
    Summary
    Predicted to enable RNA binding activity and enzyme binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Is active in synapse. Orthologous to human HNRNPUL1 (heterogeneous nuclear ribonucleoprotein U like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 34.0), testis adult (RPKM 32.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnrnpul1 in Genome Data Viewer
    Location:
    7 A3; 7 14.0 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25420586..25455695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25721161..25756268, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transforming growth factor, beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26503991-26504174 Neighboring gene coiled-coil domain containing 97 Neighboring gene STARR-seq mESC enhancer starr_18313 Neighboring gene AXL receptor tyrosine kinase Neighboring gene predicted gene, 29763 Neighboring gene cytochrome P450, family 2, subfamily s, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1. Vivori C, et al. Genome Biol, 2021 Jun 3. PMID 34082786, Free PMC Article
    2. Identification of differential protein interactors of lamin A and progerin. Kubben N, et al. Nucleus, 2010 Nov-Dec. PMID 21327095, Free PMC Article
    3. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    5. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
      Title: Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36621, MGC78330

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein U-like protein 1
    Names
    EIB-55kDa associated protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360789.1 → NP_001347718.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorer N-terminus, compared to isoform 1.
      Source sequence(s)
      AK087545, AK143666, AK155604, BY482198, CD804713
      Consensus CDS
      CCDS90188.1
      Related
      ENSMUSP00000037268.9, ENSMUST00000043765.14
      Conserved Domains (2) summary
      cd12884
      Location:112 → 289
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:324 → 469
      AAA_33; AAA domain

    2. NM_144922.3 → NP_659171.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_659171.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK087545, AK143666, AK155604, BY482198, CD804713
      Consensus CDS
      CCDS20995.1
      UniProtKB/Swiss-Prot
      Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365, Q8VDM6
      Related
      ENSMUSP00000146263.2, ENSMUST00000206832.2
      Conserved Domains (4) summary
      smart00513
      Location:3 → 37
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam13671
      Location:424 → 569
      AAA_33; AAA domain
      cd12884
      Location:212 → 389
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      cl17190
      Location:424 → 562
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. NM_178089.3 → NP_835190.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_835190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and contains an alternale 3' terminal exon, resulting in novel 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK042090, AK143666, AK155604, AW494828
      Consensus CDS
      CCDS39841.1
      UniProtKB/Swiss-Prot
      Q8VDM6
      Related
      ENSMUSP00000104038.2, ENSMUST00000108401.3
      Conserved Domains (2) summary
      smart00513
      Location:3 → 37
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12884
      Location:212 → 337
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25420586..25455695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539856.4 → XP_006539919.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006539919.1

      UniProtKB/Swiss-Prot
      Q8VDM6
      Conserved Domains (2) summary
      cd12884
      Location:112 → 289
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:324 → 469
      AAA_33; AAA domain

    2. XM_036152949.1 → XP_036008842.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1

      Conserved Domains (2) summary
      cd12884
      Location:112 → 289
      SPRY_hnRNP; SPRY domain in heterogeneous nuclear ribonucleoprotein U-like (hnRNP) protein 1
      pfam13671
      Location:324 → 469
      AAA_33; AAA domain

    3. XM_036152950.1 → XP_036008843.1  heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X2

      Conserved Domains (1) summary
      pfam13671
      Location:1 → 144
      AAA_33; AAA domain

    RNA

    1. XR_004934071.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDM6.1 GenPept UniProtKB/Swiss-Prot:Q8VDM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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