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    Otud3 OTU domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 73162, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Otud3provided by MGI
    Official Full Name
    OTU domain containing 3provided by MGI
    Primary source
    MGI:MGI:1920412
    See related
    Ensembl:ENSMUSG00000041161 AllianceGenome:MGI:1920412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110030K17Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cellular response to nutrient levels; protein deubiquitination; and protein stabilization. Predicted to act upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; protein K27-linked deubiquitination; and protein K48-linked deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in axial skeleton; olfactory epithelium; pancreas; and vomeronasal organ. Orthologous to human OTUD3 (OTU deubiquitinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 16.1), colon adult (RPKM 5.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Otud3 in Genome Data Viewer
    Location:
    4 D3; 4 70.57 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138618374..138641322, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138891063..138914026, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13030 Neighboring gene phospholipase A2, group IIE Neighboring gene predicted gene, 18097 Neighboring gene predicted gene, 33011

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. Zhang Z, et al. Mol Cell, 2020 Jul 16. PMID 32679077
    2. Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses. Cai X, et al. Cell Rep, 2022 Jun 7. PMID 35675783
    3. Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2. Jia F, et al. Cell Death Dis, 2022 Apr 30. PMID 35490179, Free PMC Article
    4. Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer. Wang M, et al. Nat Commun, 2021 Dec 1. PMID 34853315, Free PMC Article
    5. Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses. Zhou N, et al. Cell Metab, 2022 Jul 5. PMID 35675826

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
      Title: Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
    2. Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
      Title: Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
    3. Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses.
      Title: Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses.
    4. Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.
      Title: Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.
    5. Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
      Title: Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity.
    6. Knockdown of OTUD3 results in a decrease in the level of GRP78 protein, suppression of cell growth and migration, and tumorigenesis in lung cancer.
      Title: The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein K27-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within protein K6-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein K6-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    OTU domain-containing protein 3
    NP_001364018.1
    NP_001364019.1
    NP_001364020.1
    NP_082729.1
    XP_017175895.1
    XP_017175896.1
    XP_017175897.1
    XP_030109689.1
    XP_030109690.1
    XP_036020376.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377089.1 → NP_001364018.1  OTU domain-containing protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL929473
      Conserved Domains (1) summary
      cl19932
      Location:70 → 182
      OTU; OTU-like cysteine protease

    2. NM_001377090.1 → NP_001364019.1  OTU domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929473
      Conserved Domains (1) summary
      PRK10811
      Location:178 → 258
      rne; ribonuclease E; Reviewed

    3. NM_001377091.1 → NP_001364020.1  OTU domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL929473
      Conserved Domains (1) summary
      PRK10811
      Location:86 → 166
      rne; ribonuclease E; Reviewed

    4. NM_028453.2 → NP_082729.1  OTU domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_082729.1

      Status: VALIDATED

      Source sequence(s)
      AL929473
      Consensus CDS
      CCDS51337.1
      UniProtKB/Swiss-Prot
      B1AZ99
      Related
      ENSMUSP00000095441.4, ENSMUST00000097830.4
      Conserved Domains (1) summary
      cl19932
      Location:70 → 182
      OTU; OTU-like cysteine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138618374..138641322 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320408.3 → XP_017175897.1  OTU domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      PRK10811
      Location:174 → 254
      rne; ribonuclease E; Reviewed

    2. XM_030253829.2 → XP_030109689.1  OTU domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      PRK10811
      Location:174 → 254
      rne; ribonuclease E; Reviewed

    3. XM_017320406.3 → XP_017175895.1  OTU domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      PRK10811
      Location:225 → 305
      rne; ribonuclease E; Reviewed

    4. XM_036164483.1 → XP_036020376.1  OTU domain-containing protein 3 isoform X3

      Conserved Domains (1) summary
      PRK10811
      Location:127 → 207
      rne; ribonuclease E; Reviewed

    5. XM_030253830.2 → XP_030109690.1  OTU domain-containing protein 3 isoform X3

      Conserved Domains (1) summary
      PRK10811
      Location:127 → 207
      rne; ribonuclease E; Reviewed

    6. XM_017320407.3 → XP_017175896.1  OTU domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      PRK10811
      Location:225 → 305
      rne; ribonuclease E; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AZ99.1 GenPept UniProtKB/Swiss-Prot:B1AZ99

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