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    Cblc Casitas B-lineage lymphoma c [ Mus musculus (house mouse) ]

    Gene ID: 80794, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cblcprovided by MGI
    Official Full Name
    Casitas B-lineage lymphoma cprovided by MGI
    Primary source
    MGI:MGI:1931457
    See related
    Ensembl:ENSMUSG00000040525 AllianceGenome:MGI:1931457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbl3; 2310076I21Rik; 2310079L19Rik
    Summary
    Predicted to enable several functions, including SH3 domain binding activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; protein stabilization; and response to glial cell derived neurotrophic factor. Predicted to be part of ubiquitin ligase complex. Predicted to be active in membrane raft and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Orthologous to human CBLC (Cbl proto-oncogene C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 57.9), duodenum adult (RPKM 51.4) and 10 other tissues See more
    Orthologs
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    Genomic context

    See Cblc in Genome Data Viewer
    Location:
    7 A3; 7 9.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19513643..19530734, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19779718..19796809, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38955 Neighboring gene nectin cell adhesion molecule 2 Neighboring gene STARR-seq mESC enhancer starr_18217 Neighboring gene STARR-seq mESC enhancer starr_18218 Neighboring gene predicted gene, 34744 Neighboring gene STARR-seq mESC enhancer starr_18221 Neighboring gene basal cell adhesion molecule Neighboring gene STARR-positive B cell enhancer ABC_E2816 Neighboring gene STARR-seq mESC enhancer starr_18223 Neighboring gene STARR-positive B cell enhancer ABC_E1721 Neighboring gene B cell leukemia/lymphoma 3 Neighboring gene predicted gene 16174 Neighboring gene predicted gene, 34891 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20426963-20427193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20429933-20430166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:20430230-20430572

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC117886

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding  
    enables SH3 domain binding  
    enables calcium ion binding  
    enables epidermal growth factor receptor binding  
    enables epidermal growth factor receptor binding  
    enables phosphotyrosine residue binding  
    enables phosphotyrosine residue binding  
    enables protein binding PubMed 
    enables receptor tyrosine kinase binding  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway  
    involved_in negative regulation of MAP kinase activity  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor-activated receptor activity  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within protein catabolic process PubMed 
    acts_upstream_of_or_within protein stabilization PubMed 
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    acts_upstream_of_or_within response to glial cell derived neurotrophic factor PubMed 
    involved_in signal transduction  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process PubMed 
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    is_active_in membrane raft  
    is_active_in plasma membrane  
    part_of ubiquitin ligase complex PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CBL-C
    Names
    CBL-3
    RING-type E3 ubiquitin transferase CBL-C
    SH3-binding protein CBL-3
    SH3-binding protein CBL-C
    signal transduction protein CBL-C
    NP_001155316.1
    NP_075713.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161844.1NP_001155316.1  E3 ubiquitin-protein ligase CBL-C isoform 2

      See identical proteins and their annotated locations for NP_001155316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC149282
      Consensus CDS
      CCDS52064.1
      UniProtKB/TrEMBL
      G3X9U0, Q2TA94
      Related
      ENSMUSP00000104088.3, ENSMUST00000108449.9
      Conserved Domains (3) summary
      cd09920
      Location:225321
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02262
      Location:16144
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:148231
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. NM_023224.5NP_075713.3  E3 ubiquitin-protein ligase CBL-C isoform 1

      See identical proteins and their annotated locations for NP_075713.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK010228, BE198430, BQ031029
      Consensus CDS
      CCDS39804.1
      UniProtKB/Swiss-Prot
      Q80XL1, Q99PB6, Q9D6L2, Q9D7A9
      UniProtKB/TrEMBL
      Q2TA94
      Related
      ENSMUSP00000039955.8, ENSMUST00000043822.8
      Conserved Domains (4) summary
      cd09920
      Location:225321
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:350392
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02262
      Location:16144
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:148231
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19513643..19530734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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