Mettl18 methyltransferase like 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl18provided by MGI
Official Full Name: methyltransferase like 18provided by MGI
Primary source: MGI:MGI:1917212
See related: Ensembl:ENSMUSG00000041396 AllianceGenome:MGI:1917212
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810422O20Rik
Summary: Predicted to enable heat shock protein binding activity and protein-L-histidine N-tele-methyltransferase activity. Predicted to be involved in peptidyl-lysine monomethylation; regulation of gene expression; and regulation of ribosome biogenesis. Predicted to be located in cytosol and nucleolus. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human METTL18 (methyltransferase 18, RPL3 N3(tau)-histidine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 2.4), bladder adult (RPKM 2.0) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.2; 1 71.3 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (163822458..163824812)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (163994889..163997243)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables protein-L-histidine N-tele-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-L-histidine N-tele-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-L-histidine N-tele-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptidyl-lysine monomethylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine monomethylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ribosome biogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of ribosome biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translational elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational elongation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histidine protein methyltransferase 1 homolog

Names: methyltransferase-like protein 18

NP_001342061.1

EC 2.1.1.85

NP_081555.2

EC 2.1.1.85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355132.1 → NP_001342061.1 histidine protein methyltransferase 1 homolog

Status: VALIDATED

Source sequence(s)

AC110499, AK013137, AK139786, BC052693

Consensus CDS

CCDS15431.1

UniProtKB/Swiss-Prot

Q810I8, Q9CZ09

Related

ENSMUSP00000107116.2, ENSMUST00000111490.2

Conserved Domains (1) summary

cl17173
Location:155 → 314

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_027279.3 → NP_081555.2 histidine protein methyltransferase 1 homolog

See identical proteins and their annotated locations for NP_081555.2

Status: VALIDATED

Source sequence(s)

AC110499, AK139786, BC050143

Consensus CDS

CCDS15431.1

UniProtKB/Swiss-Prot

Q810I8, Q9CZ09

Related

ENSMUSP00000048636.8, ENSMUST00000045694.14

Conserved Domains (1) summary

cl17173
Location:155 → 314

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...