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    Lrrc63 leucine rich repeat containing 63 [ Mus musculus (house mouse) ]

    Gene ID: 70859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc63provided by MGI
    Official Full Name
    leucine rich repeat containing 63provided by MGI
    Primary source
    MGI:MGI:1918109
    See related
    Ensembl:ENSMUSG00000021997 AllianceGenome:MGI:1918109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921509B22Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human LRRC63 (leucine rich repeat containing 63). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 17.3) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc63 in Genome Data Viewer
    Location:
    14 D3; 14 39.59 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75321743..75368402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75084303..75130962, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37134 Neighboring gene predicted gene 4278 Neighboring gene STARR-positive B cell enhancer ABC_E10834 Neighboring gene STARR-positive B cell enhancer ABC_E757 Neighboring gene RUN and cysteine rich domain containing beclin 1 interacting protein like Neighboring gene predicted gene, 57618 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75456661-75456962 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75460374-75460674 Neighboring gene STARR-seq mESC enhancer starr_37135 Neighboring gene predicted gene 15628 Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75576489-75576789 Neighboring gene STARR-seq mESC enhancer starr_37136 Neighboring gene STARR-positive B cell enhancer ABC_E4120 Neighboring gene STARR-positive B cell enhancer ABC_E8899 Neighboring gene STARR-positive B cell enhancer ABC_E7338 Neighboring gene carboxypeptidase B2 Neighboring gene predicted gene, 35679 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 63

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404637.1 → NP_001391566.1  leucine-rich repeat-containing protein 63

      Status: VALIDATED

      Source sequence(s)
      AC129591
      UniProtKB/Swiss-Prot
      A6H694, G3X8V0, Q9D5X5

    2. NM_027581.2 → NP_081857.1  leucine-rich repeat-containing protein 63

      See identical proteins and their annotated locations for NP_081857.1

      Status: VALIDATED

      Source sequence(s)
      AC129591
      Consensus CDS
      CCDS49539.1
      UniProtKB/Swiss-Prot
      A6H694, G3X8V0, Q9D5X5
      Related
      ENSMUSP00000022574.4, ENSMUST00000022574.5
      Conserved Domains (2) summary
      COG4886
      Location:383 → 513
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:392 → 414
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      75321743..75368402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519546.1 → XP_006519609.1  leucine-rich repeat-containing protein 63 isoform X1

      See identical proteins and their annotated locations for XP_006519609.1

      UniProtKB/Swiss-Prot
      A6H694, G3X8V0, Q9D5X5
      Conserved Domains (2) summary
      COG4886
      Location:383 → 513
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:392 → 414
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_006519548.2 → XP_006519611.1  leucine-rich repeat-containing protein 63 isoform X3

    3. XM_017316193.2 → XP_017171682.1  leucine-rich repeat-containing protein 63 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H694.2 GenPept UniProtKB/Swiss-Prot:A6H694

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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