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    Cdh20 cadherin 20 [ Mus musculus (house mouse) ]

    Gene ID: 23836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdh20provided by MGI
    Official Full Name
    cadherin 20provided by MGI
    Primary source
    MGI:MGI:1346069
    See related
    Ensembl:ENSMUSG00000050840 AllianceGenome:MGI:1346069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdh7
    Summary
    Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human CDH20 (cadherin 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 5.2), frontal lobe adult (RPKM 4.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh20 in Genome Data Viewer
    Location:
    1 E2.1; 1 49.42 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (104696245..104923202)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (104768340..104995481)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41924 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene phosphatidylinositol transfer protein, cytoplasmic 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01830 Neighboring gene STARR-seq mESC enhancer starr_01832 Neighboring gene STARR-seq mESC enhancer starr_01833 Neighboring gene STARR-seq mESC enhancer starr_01835 Neighboring gene STARR-seq mESC enhancer starr_01837 Neighboring gene STARR-seq mESC enhancer starr_01838 Neighboring gene predicted gene, 53576 Neighboring gene STARR-seq mESC enhancer starr_01839 Neighboring gene STARR-seq mESC enhancer starr_01840 Neighboring gene predicted gene, 41925 Neighboring gene predicted gene 29012 Neighboring gene STARR-seq mESC enhancer starr_01841 Neighboring gene ring finger protein 152 Neighboring gene predicted gene, 17634

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation. Moore R, et al. Oncogene, 2004 Sep 2. PMID 15273735
    2. Cloning and expression of mouse Cadherin-7, a type-II cadherin isolated from the developing eye. Faulkner-Jones BE, et al. Mol Cell Neurosci, 1999 Jul. PMID 10433813
    3. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
    4. GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools. Haase G, et al. Neuron, 2002 Aug 29. PMID 12372284
    5. Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Polanco J, et al. Front Mol Neurosci, 2021. PMID 33833667, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Melanoma cell lines contained transcripts for cadherin-7 but not for cadherin-20.
      Title: Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141415

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-20
    Names
    cadherin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420677.1 → NP_001407606.1  cadherin-20 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101970, AC124447, AC158931

    2. NM_011800.6 → NP_035930.1  cadherin-20 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035930.1

      Status: VALIDATED

      Source sequence(s)
      AC101970, AC124447, AC158931
      Consensus CDS
      CCDS15203.1
      UniProtKB/Swiss-Prot
      Q9Z0M3
      Related
      ENSMUSP00000052078.9, ENSMUST00000062528.9
      Conserved Domains (3) summary
      cd11304
      Location:394 → 490
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:85 → 163
      CA; Cadherin repeats
      pfam01049
      Location:643 → 794
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      104696245..104923202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0M3.1 GenPept UniProtKB/Swiss-Prot:Q9Z0M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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