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    Itga9 integrin alpha 9 [ Mus musculus (house mouse) ]

    Gene ID: 104099, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Itga9provided by MGI
    Official Full Name
    integrin alpha 9provided by MGI
    Primary source
    MGI:MGI:104756
    See related
    Ensembl:ENSMUSG00000039115 AllianceGenome:MGI:104756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    (alpha)9; D130073C02; D9Ertd428e; 2610002H11Rik; 6720458D17Rik
    Summary
    Enables integrin binding activity involved in cell-matrix adhesion. Acts upstream of or within neutrophil chemotaxis. Located in basal plasma membrane. Part of integrin alpha9-beta1 complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Used to study congenital chylothorax. Human ortholog(s) of this gene implicated in cerebral infarction; hypertension; and pancreatic cancer. Orthologous to human ITGA9 (integrin subunit alpha 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 10.7), ovary adult (RPKM 10.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itga9 in Genome Data Viewer
    Location:
    9 F3; 9 70.32 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118435777..118730071)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118606709..118901003)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33460 Neighboring gene STARR-seq mESC enhancer starr_25460 Neighboring gene golgin A4 Neighboring gene family with sequence similarity 64, member A pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118586586-118586773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118623570-118623818 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118625206-118625362 Neighboring gene STARR-seq mESC enhancer starr_25461 Neighboring gene STARR-positive B cell enhancer mm9_chr9:118780330-118780630 Neighboring gene predicted gene 10157 Neighboring gene predicted gene, 39454 Neighboring gene uncharacterized LOC102636563 Neighboring gene predicted gene, 51695 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118834312-118834499 Neighboring gene CTD small phosphatase like Neighboring gene VISTA enhancer mm1627 Neighboring gene STARR-seq mESC enhancer starr_25464 Neighboring gene predicted gene, 53514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Chen C, et al. Immunity, 2006 Dec. PMID 17137800
    2. Integrin α9 regulates smooth muscle cell phenotype switching and vascular remodeling. Jain M, et al. JCI Insight, 2021 May 24. PMID 34027892, Free PMC Article
    3. Blockade of interaction of alpha9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing. Nakayama Y, et al. Lab Invest, 2010 Jun. PMID 20308983
    4. Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1. Huang XZ, et al. Mol Cell Biol, 2000 Jul. PMID 10866676, Free PMC Article
    5. Targeting myeloid-cell specific integrin α9β1 inhibits arterial thrombosis in mice. Dhanesha N, et al. Blood, 2020 Mar 12. PMID 31951649, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrin-alpha9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia.
      Title: Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia.
    2. Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
      Title: Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
    3. study provides in vitro and in vivo evidence that the interaction between XCL1 and alpha9 integrin has an important role for autoimmune diseases
      Title: A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.
    4. A novel motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved mouse OPN binds to alpha9beta1 integrin.
      Title: A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis.
    5. Notch signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin EIIIA expression during valve morphogenesis
      Title: Notch signaling functions in lymphatic valve formation.
    6. alpha9beta1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis.
      Title: α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis.
    7. Integrin alpha9 on lymphatic endothelial cells regulates lymphocyte egress.
      Title: Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
    8. EMILIN1/integrin alpha 9 beta 1 interaction contributes to lymphatic valve formation, maintenance, and function.
      Title: EMILIN1/α9β1 integrin interaction is crucial in lymphatic valve formation and maintenance.
    9. alpha(4) and alpha(9) integrins interacting with OPN via the SLAYGLR domain play a key role in macrophage biology by regulating migration, survival, and accumulation.
      Title: Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.
    10. integrin alpha9beta1 appears to serve as a brake on airway smooth muscle contraction by recruiting SSAT, which facilitates local catabolism of polyamines and thereby inhibits PIP5K1gamma.
      Title: Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding involved in cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin alpha9-beta1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin alpha9-beta1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113514.1 → NP_001106986.1  integrin alpha-9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC156800, AK139690, CF913701
      Consensus CDS
      CCDS52961.1
      UniProtKB/TrEMBL
      E9QAP0, Q8BJG9
      Related
      ENSMUSP00000122417.2, ENSMUST00000124360.8
      Conserved Domains (1) summary
      pfam08441
      Location:2 → 318
      Integrin_alpha2; Integrin alpha

    2. NM_133721.2 → NP_598482.2  integrin alpha-9 isoform a precursor

      See identical proteins and their annotated locations for NP_598482.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC156800, AK153585, BB638856, CN698186
      Consensus CDS
      CCDS23604.1
      UniProtKB/Swiss-Prot
      B8JK39, B9EKC4
      UniProtKB/TrEMBL
      Q91YD5
      Related
      ENSMUSP00000044227.8, ENSMUST00000044165.14
      Conserved Domains (2) summary
      smart00191
      Location:362 → 415
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:460 → 904
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      118435777..118730071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B8JK39.1 GenPept UniProtKB/Swiss-Prot:B8JK39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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