Mtmr7 myotubularin related protein 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtmr7provided by MGI
Official Full Name: myotubularin related protein 7provided by MGI
Primary source: MGI:MGI:1891693
See related: Ensembl:ENSMUSG00000039431 AllianceGenome:MGI:1891693
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables inositol bisphosphate phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; peripheral nervous system ganglion; sensory organ; and urinary system. Orthologous to human MTMR7 (myotubularin related protein 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 9.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (41003184..41088210, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (40548199..40634935, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism.
Title: MTMR7 suppresses the phenotypic switching of vascular smooth muscle cell and vascular intimal hyperplasia after injury via regulating p62/mTORC1-mediated glucose metabolism.
Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
Title: Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling.
The improved proliferation capacity was related to the increased phosphorylation of AKT. Taken together, our research demonstrates that MTMR7 plays an important role in proliferation and early differentiation of C2C12 myoblast.
Title: Silencing myotubularin related protein 7 enhances proliferation and early differentiation of C2C12 myoblast.
MTMR7 forms a complex with MTMR9 and dephosphorylates phosphatidylinositol 3-phosphate and Ins(1,3)P2 in neuronal cells.
Title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inositol bisphosphate phosphatase activity	EXP Inferred from Experiment more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol-3-phosphate phosphatase MTMR7; myotubularin-related protein 7

Names: inositol 1,3-bisphosphate phosphatase; phosphatidylinositol-3-phosphate phosphatase

NP_001035789.1

EC 3.1.3.64

NP_001412577.1

EC 3.1.3.64

XP_006509530.1

EC 3.1.3.64

XP_006509532.1

EC 3.1.3.64

XP_036010070.1

EC 3.1.3.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040699.2 → NP_001035789.1 phosphatidylinositol-3-phosphate phosphatase MTMR7 isoform 1

See identical proteins and their annotated locations for NP_001035789.1

Status: VALIDATED

Source sequence(s)

AC121140

Consensus CDS

CCDS40324.1

UniProtKB/Swiss-Prot

Q8C4J6, Q9Z2C9

Related

ENSMUSP00000043851.11, ENSMUST00000048898.17

Conserved Domains (2) summary

cd13344
Location:1 → 103

PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam06602
Location:109 → 446

Myotub-related; Myotubularin-like phosphatase domain
NM_001425648.1 → NP_001412577.1 phosphatidylinositol-3-phosphate phosphatase MTMR7 isoform 2

Status: VALIDATED

Source sequence(s)

AC121140

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

41003184..41088210 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154177.1 → XP_036010070.1 myotubularin-related protein 7 isoform X2

Conserved Domains (1) summary

cl28904
Location:1 → 212

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006509467.5 → XP_006509530.1 myotubularin-related protein 7 isoform X2

See identical proteins and their annotated locations for XP_006509530.1

Conserved Domains (1) summary

cl28904
Location:1 → 212

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_006509469.5 → XP_006509532.1 myotubularin-related protein 7 isoform X3

Conserved Domains (1) summary

pfam06602
Location:1 → 151

Myotub-related; Myotubularin-like phosphatase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019433.1: Suppressed sequence

Description

NM_019433.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.