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    Art2b ADP-ribosyltransferase 2b [ Mus musculus (house mouse) ]

    Gene ID: 11872, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Art2bprovided by MGI
    Official Full Name
    ADP-ribosyltransferase 2bprovided by MGI
    Primary source
    MGI:MGI:107545
    See related
    Ensembl:ENSMUSG00000030651 AllianceGenome:MGI:107545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Art; Rt6; Rt-6; ARTC2; Ly92b; Rt6-2; ART2.2
    Summary
    Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. Orthologous to human ART2BP (ADP-ribosyltransferase 2B, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 3.9), mammary gland adult (RPKM 1.9) and 6 other tissues See more
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    Genomic context

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    See Art2b in Genome Data Viewer
    Location:
    7 E2; 7 54.61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101224936..101234790, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101575729..101585591, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19765 Neighboring gene ADP-ribosyltransferase 2a Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 45995 Neighboring gene STARR-seq mESC enhancer starr_19695 Neighboring gene STARR-positive B cell enhancer ABC_E10456 Neighboring gene STARR-positive B cell enhancer ABC_E4958 Neighboring gene STARR-seq mESC enhancer starr_19696 Neighboring gene ClpB caseinolytic peptidase B Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2. Menzel S, et al. J Immunol, 2015 Sep 1. PMID 26209623
    2. Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death. Bannas P, et al. Mol Immunol, 2011 Sep. PMID 21641039
    3. Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts. Bannas P, et al. Blood, 2005 May 1. PMID 15657180
    4. A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo. Gondé H, et al. Front Immunol, 2021. PMID 34489954, Free PMC Article
    5. Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies. Georgiev H, et al. Eur J Immunol, 2018 Jun. PMID 29508376

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo.
      Title: A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo.
    2. Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation.
      Title: Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation.
    3. this study shows that blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies
      Title: Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies.
    4. Data show that shedding of T Cell Ecto-ADP-ribosyltransferase ARTC2.2 alters its substrate profile.
      Title: Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.
    5. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
      Title: Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
    6. Extracellular nicotinamide adenine dinucleotide (NAD)/ART2-dependent modification of the P2X7R purinergic receptor potentiates the ability of adenosine triphosphate (ATP) to activate the receptor, via a left shift in the ATP dose-response relationship.
      Title: Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
    7. Transfer of a genetically disrupted CD38 allele into the autoimmune diabetes-prone NOD/Lt background accelerated diabetes onset in both sexes, whereas transfer of a disrupted ART2a/b complex had no effect.
      Title: Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
    8. ART2b is required for ADP-ribosylation of cell surface proteins
      Title: Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
    9. CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2.
      Title: CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
    10. raft association focuses ART2.2 on specific targets that constitutively or inducibly associate with lipid rafts
      Title: Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extrinsic component of plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    T-cell ecto-ADP-ribosyltransferase 2
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 2
    NAD(+) glycohydrolase
    T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2
    T-cell differentiation marker Rt6 homolog 2
    T-cell mono(ADP-ribosyl)transferase 2
    mono(ADP-ribosyl)transferase 2B
    NP_064299.2
    XP_006507319.1
    XP_017177440.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019915.3 → NP_064299.2  T-cell ecto-ADP-ribosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_064299.2

      Status: VALIDATED

      Source sequence(s)
      AC129609, AF016465
      Consensus CDS
      CCDS21512.1
      UniProtKB/Swiss-Prot
      F8VQK8, O35702, O35975
      UniProtKB/TrEMBL
      A0A1B0GQV6
      Related
      ENSMUSP00000065658.3, ENSMUST00000063920.3
      Conserved Domains (1) summary
      pfam01129
      Location:27 → 242
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101224936..101234790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507256.4 → XP_006507319.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

      See identical proteins and their annotated locations for XP_006507319.1

      UniProtKB/Swiss-Prot
      F8VQK8, O35702, O35975
      UniProtKB/TrEMBL
      A0A1B0GQV6
      Related
      ENSMUSP00000147267.2, ENSMUST00000209526.2
      Conserved Domains (1) summary
      pfam01129
      Location:27 → 242
      ART; NAD:arginine ADP-ribosyltransferase

    2. XM_017321951.2 → XP_017177440.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GQV6
      Conserved Domains (1) summary
      pfam01129
      Location:38 → 253
      ART; NAD:arginine ADP-ribosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35975.2 GenPept UniProtKB/Swiss-Prot:O35975

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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