Tax1bp1 Tax1 (human T cell leukemia virus type I) binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tax1bp1provided by MGI
Official Full Name: Tax1 (human T cell leukemia virus type I) binding protein 1provided by MGI
Primary source: MGI:MGI:1289308
See related: Ensembl:ENSMUSG00000004535 AllianceGenome:MGI:1289308
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T6bp; TXBP151; D6Ertd404e; D6Ertd772e; 1200003J11Rik; 1700069J21Rik
Summary: Enables kinase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity. Predicted to be located in autophagosome; cytoplasmic vesicle; and phagophore assembly site. Predicted to be active in mitochondrion. Is expressed in central nervous system; genital tubercle; limb mesenchyme; and retina nuclear layer. Orthologous to human TAX1BP1 (Tax1 binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 37.5), testis adult (RPKM 35.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 25.7 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (52690677..52743765)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (52713692..52766780)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction.
Title: TAX1BP1 downregulation by STAT3 in cardiac fibroblasts contributes to diabetes-induced heart failure with preserved ejection fraction.
Multifaceted roles of TAX1BP1 in autophagy.
Title: Multifaceted roles of TAX1BP1 in autophagy.
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
Title: Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages.
Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
Title: Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis.
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
Title: Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.
TAX1BP1 overexpression promoted autophagic flux, as demonstrated by increased LC3-RFP fluorescence in vitro. Furthermore, the autophagy inhibitor 3-MA abolished the protective effects of TAX1BP1 in vivo.
Title: TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy.
These findings show that TAX1BP1 restricts ERK activation and Blimp-1 expression and regulates germinal center formation.
Title: Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.
These studies reveal that TAX1BP1 drives a specialized form of autophagy, providing critical amino acids that activate mTOR and enable the metabolic transition of activated T cells.
Title: The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.
The induction of antibodies to an AQP4 epitope in mice immunized with the TAX1BP1-derived peptide suggests that a latent HTLV-1 infection could lead to TAX1BP1 antigen presentation and the production of anti-AQP4 antibodies in human neuromyelitis optica.
Title: Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.
Antibiotics-induced 'germ free' status or the additional MyD88 deficiency significantly ameliorated TAX1BP1-KO mice's inflammatory lesions
Title: Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC31789 (e-PCR)
- UniSTS:2823

AA930106 (e-PCR)
- UniSTS:159508

RH127165 (e-PCR)
- UniSTS:167486

D6Ertd772e (e-PCR), detects polymorphism
- UniSTS:167500

RH65631 (e-PCR)
- UniSTS:64116

RH136356 (e-PCR)
- UniSTS:210346

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to phagocytic vesicle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to phagocytic vesicle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tax1-binding protein 1 homolog

Names: TRAF6-binding protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355595.1 → NP_001342524.1 tax1-binding protein 1 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AC099741, AC117212, BP754065

Conserved Domains (1) summary

cl25732
Location:17 → 398

SMC_N; RecF/RecN/SMC N terminal domain
NM_001355596.1 → NP_001342525.1 tax1-binding protein 1 homolog isoform 1

Status: VALIDATED

Source sequence(s)

AC099741, AC117212, BP754065

Consensus CDS

CCDS39490.1

UniProtKB/Swiss-Prot

Q3UKC1, Q91YT6, Q9CVF0, Q9DC45

Conserved Domains (1) summary

cl25732
Location:17 → 460

SMC_N; RecF/RecN/SMC N terminal domain
NM_025816.3 → NP_080092.2 tax1-binding protein 1 homolog isoform 1

See identical proteins and their annotated locations for NP_080092.2

Status: VALIDATED

Source sequence(s)

AC099741, AK146076, BP754065

Consensus CDS

CCDS39490.1

UniProtKB/Swiss-Prot

Q3UKC1, Q91YT6, Q9CVF0, Q9DC45

Related

ENSMUSP00000079548.5, ENSMUST00000080723.11

Conserved Domains (1) summary

cl25732
Location:17 → 460

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

52690677..52743765

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506370.5 → XP_006506433.1 tax1-binding protein 1 homolog isoform X1

Conserved Domains (4) summary

COG4372
Location:338 → 645

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

pfam07888
Location:125 → 408

CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like

pfam17751
Location:17 → 120

SKICH; SKICH domain

pfam18112
Location:704 → 730

Zn-C2H2_12; Autophagy receptor zinc finger-C2H2 domain