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    Mix23 mitochondrial matrix import factor 23 [ Mus musculus (house mouse) ]

    Gene ID: 381045, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mix23provided by MGI
    Official Full Name
    mitochondrial matrix import factor 23provided by MGI
    Primary source
    MGI:MGI:2146423
    See related
    Ensembl:ENSMUSG00000075229 AllianceGenome:MGI:2146423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc58; A930007B11Rik
    Summary
    Located in mitochondrion. Orthologous to human MIX23 (mitochondrial matrix import factor 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 11.7), CNS E11.5 (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mix23 in Genome Data Viewer
    Location:
    16 B3; 16 25.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35892030..35912488)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36071660..36092118)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5540 Neighboring gene WD repeat domain 5B Neighboring gene family with sequence similarity 162, member A Neighboring gene STARR-seq mESC enhancer starr_40755 Neighboring gene STARR-seq mESC enhancer starr_40756 Neighboring gene STARR-seq mESC enhancer starr_40757 Neighboring gene predicted gene, 41450 Neighboring gene STARR-seq mESC enhancer starr_40758 Neighboring gene cystatin A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Pham AH, et al. Cells, 2024 May 8. PMID 38786026, Free PMC Article
    2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36453

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein MIX23
    Names
    coiled-coil domain containing 58
    coiled-coil domain-containing protein 58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159421.1 → NP_001152893.1  protein MIX23 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK135450, BB686073, CB949450, CF617453, CJ094333
      Consensus CDS
      CCDS49838.1
      UniProtKB/TrEMBL
      E9Q4B5
      Related
      ENSMUSP00000131929.2, ENSMUST00000163352.9
      Conserved Domains (1) summary
      pfam09774
      Location:9 → 92
      Cid2; Caffeine-induced death protein 2

    2. NM_001159422.1 → NP_001152894.1  protein MIX23 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK135450, AV583692, BB686073
      Consensus CDS
      CCDS49839.1
      UniProtKB/TrEMBL
      F8WJI3
      Related
      ENSMUSP00000097520.5, ENSMUST00000099937.6
      Conserved Domains (1) summary
      pfam09774
      Location:1 → 124
      Cid2; Caffeine-induced death protein 2

    3. NM_198645.2 → NP_941047.1  protein MIX23 isoform 1

      See identical proteins and their annotated locations for NP_941047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK135450, BB686073, CB949450, CF617453
      Consensus CDS
      CCDS28147.1
      UniProtKB/Swiss-Prot
      Q3UXM5, Q8R3Q6
      Related
      ENSMUSP00000125874.2, ENSMUST00000164916.9
      Conserved Domains (1) summary
      pfam09774
      Location:10 → 134
      Cid2; Caffeine-induced death protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      35892030..35912488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3Q6.1 GenPept UniProtKB/Swiss-Prot:Q8R3Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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