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    Tango6 transport and golgi organization 6 [ Mus musculus (house mouse) ]

    Gene ID: 272538, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tango6provided by MGI
    Official Full Name
    transport and golgi organization 6provided by MGI
    Primary source
    MGI:MGI:2142786
    See related
    Ensembl:ENSMUSG00000041949 AllianceGenome:MGI:2142786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmco7; E330010G16
    Summary
    Predicted to be involved in protein secretion. Predicted to be located in membrane. Is expressed in aorta; genitourinary system; gut gland; and heart. Orthologous to human TANGO6 (transport and golgi organization 6 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 3.7), subcutaneous fat pad adult (RPKM 2.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tango6 in Genome Data Viewer
    Location:
    8 D3; 8 53.18 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107409697..107581175)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106683068..106851439)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110028F18 gene Neighboring gene predicted gene, 39239 Neighboring gene STARR-seq mESC enhancer starr_22570 Neighboring gene cadherin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109171364-109171664 Neighboring gene STARR-seq mESC enhancer starr_22578 Neighboring gene STARR-positive B cell enhancer ABC_E10521 Neighboring gene STARR-seq mESC enhancer starr_22579 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109344486-109344787 Neighboring gene predicted gene, 34197 Neighboring gene STARR-seq mESC enhancer starr_22582 Neighboring gene predicted gene, 53451 Neighboring gene ES cell cis-regulatory motif 8a Neighboring gene hyaluronan synthase 3 Neighboring gene CTF8, chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Feng Z, et al. Nat Commun, 2024 Mar 15. PMID 38490996, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.
      Title: TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization protein 6 homolog
    Names
    transmembrane and coiled-coil domain-containing protein 7
    transmembrane and coiled-coil domains 7
    transport and Golgi organization 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173037.2 → NP_766625.1  transport and Golgi organization protein 6 homolog

      See identical proteins and their annotated locations for NP_766625.1

      Status: VALIDATED

      Source sequence(s)
      AC140328, AC147500
      Consensus CDS
      CCDS22639.1
      UniProtKB/Swiss-Prot
      Q69ZB6, Q6NXV4, Q8C3S2, Q8C6M0, Q8C8G2
      Related
      ENSMUSP00000043953.5, ENSMUST00000048359.5
      Conserved Domains (3) summary
      pfam10304
      Location:1027 → 1059
      RTP1_C2; Required for nuclear transport of RNA pol II C-terminus 2
      pfam10363
      Location:826 → 929
      RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1
      sd00044
      Location:861 → 889
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107409697..107581175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C3S2.1 GenPept UniProtKB/Swiss-Prot:Q8C3S2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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