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    Spred3 sprouty-related EVH1 domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 101809, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spred3provided by MGI
    Official Full Name
    sprouty-related EVH1 domain containing 3provided by MGI
    Primary source
    MGI:MGI:2142186
    See related
    Ensembl:ENSMUSG00000037239 AllianceGenome:MGI:2142186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spred-3; D130060H24Rik
    Summary
    Predicted to enable protein kinase binding activity. Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; extraembryonic component; and pancreas. Orthologous to human SPRED3 (sprouty related EVH1 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 9.5), cortex adult (RPKM 5.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spred3 in Genome Data Viewer
    Location:
    7 B1; 7 16.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28857208..28869286, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29157783..29170070, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 1, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_18458 Neighboring gene microRNA 1963 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29926525-29926755 Neighboring gene RAS guanyl releasing protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E9287 Neighboring gene family with sequence similarity 98, member C Neighboring gene STARR-positive B cell enhancer ABC_E8159 Neighboring gene STARR-positive B cell enhancer ABC_E1337 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Neighboring gene gametogenetin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of TGFβ-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. Zhao G, et al. Exp Eye Res, 2015 Mar. PMID 25576668
    2. Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred. Zhao G, et al. Exp Eye Res, 2018 May. PMID 29501879, Free PMC Article
    3. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. Kato R, et al. Biochem Biophys Res Commun, 2003 Mar 21. PMID 12646235
    4. Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Sylvestersen KB, et al. Gene Expr Patterns, 2011 Jan-Feb. PMID 20934536
    5. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables stem cell factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of lens fiber cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sprouty-related, EVH1 domain-containing protein 3
    Names
    Sprouty-related EVH1 domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182927.3 → NP_891557.3  sprouty-related, EVH1 domain-containing protein 3

      See identical proteins and their annotated locations for NP_891557.3

      Status: VALIDATED

      Source sequence(s)
      BC062119, CF538218, EL606697
      Consensus CDS
      CCDS21065.1
      UniProtKB/Swiss-Prot
      Q6P6N5, Q7TNJ8
      UniProtKB/TrEMBL
      A0A0R4J0K0
      Related
      ENSMUSP00000046216.7, ENSMUST00000048923.7
      Conserved Domains (2) summary
      cd10574
      Location:2 → 105
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:294 → 391
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28857208..28869286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030241962.2 → XP_030097822.1  sprouty-related, EVH1 domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      cd10574
      Location:93 → 198
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain

    2. XM_017321915.3 → XP_017177404.1  sprouty-related, EVH1 domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      cd10574
      Location:93 → 198
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6N5.1 GenPept UniProtKB/Swiss-Prot:Q6P6N5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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