Crebzf CREB/ATF bZIP transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crebzfprovided by MGI
Official Full Name: CREB/ATF bZIP transcription factorprovided by MGI
Primary source: MGI:MGI:2675296
See related: Ensembl:ENSMUSG00000051451 AllianceGenome:MGI:2675296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zf; LAZip; SMILE; LAZipII; 1110034C16Rik; 6330417B10Rik
Summary: Predicted to enable identical protein binding activity and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic; regulation of DNA-templated transcription; and response to virus. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including early embryo; foot mesenchyme; nervous system; retina; and uterus. Orthologous to human CREBZF (CREB/ATF bZIP transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 27.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 50.59 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (90091942..90097590)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (90442734..90448382)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
Title: Macrophage CREBZF Orchestrates Inflammatory Response to Potentiate Insulin Resistance and Type 2 Diabetes.
Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
Title: Intrahepatic osteopontin signaling by CREBZF defines a checkpoint for steatosis-to-NASH progression.
Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation.
Title: Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation.
[Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth].
Title: [Biological functions of CREB/ATF bZIP transcription factor in metabolism and cell growth].
Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY.
Title: Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY.
CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice.
Title: CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice.
these results suggest that CREBZF might play a proapoptotic role in cell apoptosis in granulosa cells, possibly by regulating the ERK1/2 and mTOR signaling pathways
Title: Activation of CREBZF Increases Cell Apoptosis in Mouse Ovarian Granulosa Cells by Regulating the ERK1/2 and mTOR Signaling Pathways.
SMILE is an insulin-inducible corepressor that suppresses hepatic gluconeogenesis.
Title: Insulin-Inducible SMILE Inhibits Hepatic Gluconeogenesis.
Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor gamma activity.
Title: Small heterodimer partner-interacting leucine zipper protein inhibits adipogenesis by regulating peroxisome proliferator-activated receptor γ activity.
Taken together, these findings demonstrate that SMILE negatively regulates osteocalcin via a direct interaction with RUNX2
Title: SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135967 (e-PCR)
- UniSTS:209963

Crebzf (e-PCR), detects polymorphism
- UniSTS:547203

AI606244 (e-PCR)
- UniSTS:165540

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CREB/ATF bZIP transcription factor

Names: HCF-binding transcription factor Zhangfei; host cell factor-binding transcription factor Zhangfei; tyrosine kinase-associated leucine zipper protein LAZip; tyrosine kinase-associated leucine zipper protein LAZipII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145151.3 → NP_660133.2 CREB/ATF bZIP transcription factor

See identical proteins and their annotated locations for NP_660133.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.

Source sequence(s)

AC100322, AK004085

Consensus CDS

CCDS40020.1

UniProtKB/Swiss-Prot

Q91Y72, Q91ZR3

Related

ENSMUSP00000050972.6, ENSMUST00000061767.5

Conserved Domains (1) summary

cl21462
Location:223 → 264

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

RNA

NR_073436.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC100322, AK004085, BI990274
NR_073437.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC100322, CX237465
NR_073438.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks three alternate internal segments, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA028814, AC100322, BG094109

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

90091942..90097590

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507606.2 → XP_006507669.1 CREB/ATF bZIP transcription factor isoform X1

See identical proteins and their annotated locations for XP_006507669.1

UniProtKB/Swiss-Prot

Q91Y72, Q91ZR3

Conserved Domains (1) summary

cl21462
Location:223 → 264

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain