Slc25a27 solute carrier family 25, member 27 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a27provided by MGI
Official Full Name: solute carrier family 25, member 27provided by MGI
Primary source: MGI:MGI:1921261
See related: Ensembl:ENSMUSG00000023912 AllianceGenome:MGI:1921261
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ucp4; UCP 4; 3632410G24Rik; 9430092A03Rik; D530043E16Rik
Summary: Predicted to enable chloride transmembrane transporter activity; protein homodimerization activity; and proton transmembrane transporter activity. Acts upstream of or within negative regulation of neuron apoptotic process. Located in mitochondrial inner membrane. Is expressed in central nervous system; neural retina; peripheral nervous system ganglion; and trigeminal nerve. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SLC25A27 (solute carrier family 25 member 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 9.6), CNS E18 (RPKM 8.3) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.75 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (43948630..43978105, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43637739..43667214, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.
Title: Ucp4 Knockdown of Cerebellar Purkinje Cells Induces Bradykinesia.
Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
Title: Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease.
our results suggested DJ-1 might regulate the expression of UCP4 by oxidation of DJ-1 and partially via NF-kappaB pathway in its protective response to oxidative stress
Title: Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.
UCP4 may dissipate the excessive proton gradient, which is usually associated with reactive oxygen species production.
Title: Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.
astrocytes expressing more UCP4 produce more lactate, which is used as an energy source by neurons, and have the ability to enhance neuronal survival
Title: Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival.
UCP2 is present in cells with highly proliferative potential, which have a glycolytic type of metabolism as a common feature, whereas UCP4 is strongly associated with non-proliferative highly differentiated neuronal cells
Title: Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function.
Adipocytes overexpressing UcpP4 showed decreased mitochondrial copy number (mtDNA) and lower mRNA expression of key factors in mitochondrial biogenesis, including PGC-1alpha and mtTFA.
Title: Mitochondrial dysfunction is induced by the overexpression of UCP4 in 3T3-L1 adipocytes.
Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.
Title: Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

D17Mit215 (e-PCR), detects polymorphism
- UniSTS:128030

Slc25a27 (e-PCR), detects polymorphism
- UniSTS:545994

AI035719 (e-PCR)
- UniSTS:160232

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chloride transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in response to cold	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial uncoupling protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357122.1 → NP_001344051.1 mitochondrial uncoupling protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC154647, AU254602

UniProtKB/TrEMBL

Q9CX10

Conserved Domains (1) summary

pfam00153
Location:122 → 218

Mito_carr; Mitochondrial carrier protein
NM_001357123.1 → NP_001344052.1 mitochondrial uncoupling protein 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC154647, AU254602

Conserved Domains (1) summary

pfam00153
Location:136 → 232

Mito_carr; Mitochondrial carrier protein
NM_028711.4 → NP_082987.1 mitochondrial uncoupling protein 4 isoform 1

See identical proteins and their annotated locations for NP_082987.1

Status: VALIDATED

Source sequence(s)

AC154647, AK043831, AU254602

Consensus CDS

CCDS28798.1

UniProtKB/Swiss-Prot

Q9D6D0

UniProtKB/TrEMBL

Q9CX10

Related

ENSMUSP00000024705.5, ENSMUST00000024705.6

Conserved Domains (2) summary

PTZ00169
Location:22 → 316

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:122 → 218

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

43948630..43978105 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250096.1 → XP_030105956.1 mitochondrial uncoupling protein 4 isoform X10

Conserved Domains (1) summary

pfam00153
Location:20 → 114

Mito_carr; Mitochondrial carrier protein
XM_030250101.2 → XP_030105961.1 mitochondrial uncoupling protein 4 isoform X12

Conserved Domains (1) summary

pfam00153
Location:7 → 98

Mito_carr; Mitochondrial carrier protein
XM_030250100.1 → XP_030105960.1 mitochondrial uncoupling protein 4 isoform X12

Conserved Domains (1) summary

pfam00153
Location:7 → 98

Mito_carr; Mitochondrial carrier protein
XM_030250091.2 → XP_030105951.1 mitochondrial uncoupling protein 4 isoform X6

Conserved Domains (1) summary

pfam00153
Location:77 → 171

Mito_carr; Mitochondrial carrier protein
XM_017317679.3 → XP_017173168.1 mitochondrial uncoupling protein 4 isoform X2

Conserved Domains (1) summary

pfam00153
Location:138 → 232

Mito_carr; Mitochondrial carrier protein
XM_030250102.1 → XP_030105962.1 mitochondrial uncoupling protein 4 isoform X12

Conserved Domains (1) summary

pfam00153
Location:7 → 98

Mito_carr; Mitochondrial carrier protein
XM_006525001.4 → XP_006525064.1 mitochondrial uncoupling protein 4 isoform X3

UniProtKB/TrEMBL

Q9CX10

Conserved Domains (1) summary

pfam00153
Location:124 → 218

Mito_carr; Mitochondrial carrier protein
XM_017317681.3 → XP_017173170.1 mitochondrial uncoupling protein 4 isoform X5

Conserved Domains (1) summary

pfam00153
Location:77 → 171

Mito_carr; Mitochondrial carrier protein
XM_030250095.2 → XP_030105955.1 mitochondrial uncoupling protein 4 isoform X10

Conserved Domains (1) summary

pfam00153
Location:20 → 114

Mito_carr; Mitochondrial carrier protein
XM_030250103.2 → XP_030105963.1 mitochondrial uncoupling protein 4 isoform X12

Conserved Domains (1) summary

pfam00153
Location:7 → 98

Mito_carr; Mitochondrial carrier protein
XM_030250099.2 → XP_030105959.1 mitochondrial uncoupling protein 4 isoform X12

Conserved Domains (1) summary

pfam00153
Location:7 → 98

Mito_carr; Mitochondrial carrier protein
XM_017317678.3 → XP_017173167.1 mitochondrial uncoupling protein 4 isoform X1

Conserved Domains (1) summary

pfam00153
Location:138 → 232

Mito_carr; Mitochondrial carrier protein
XM_030250092.2 → XP_030105952.1 mitochondrial uncoupling protein 4 isoform X8

Conserved Domains (1) summary

pfam00153
Location:20 → 114

Mito_carr; Mitochondrial carrier protein
XM_036160809.1 → XP_036016702.1 mitochondrial uncoupling protein 4 isoform X4

Conserved Domains (1) summary

pfam00153
Location:119 → 215

Mito_carr; Mitochondrial carrier protein
XM_030250098.2 → XP_030105958.1 mitochondrial uncoupling protein 4 isoform X11

Conserved Domains (1) summary

pfam00153
Location:2 → 98

Mito_carr; Mitochondrial carrier protein
XM_036160814.1 → XP_036016707.1 mitochondrial uncoupling protein 4 isoform X11

Conserved Domains (1) summary

pfam00153
Location:2 → 98

Mito_carr; Mitochondrial carrier protein
XM_036160812.1 → XP_036016705.1 mitochondrial uncoupling protein 4 isoform X11

Conserved Domains (1) summary

pfam00153
Location:2 → 98

Mito_carr; Mitochondrial carrier protein
XM_030250094.2 → XP_030105954.1 mitochondrial uncoupling protein 4 isoform X9

Conserved Domains (1) summary

pfam00153
Location:20 → 114

Mito_carr; Mitochondrial carrier protein
XM_036160813.1 → XP_036016706.1 mitochondrial uncoupling protein 4 isoform X11

Conserved Domains (1) summary

pfam00153
Location:2 → 98

Mito_carr; Mitochondrial carrier protein
XM_030250093.2 → XP_030105953.1 mitochondrial uncoupling protein 4 isoform X9

Conserved Domains (1) summary

pfam00153
Location:20 → 114

Mito_carr; Mitochondrial carrier protein
XM_036160811.1 → XP_036016704.1 mitochondrial uncoupling protein 4 isoform X11

Conserved Domains (1) summary

pfam00153
Location:2 → 98

Mito_carr; Mitochondrial carrier protein
XM_017317682.3 → XP_017173171.1 mitochondrial uncoupling protein 4 isoform X7

Conserved Domains (1) summary

pfam00153
Location:138 → 232

Mito_carr; Mitochondrial carrier protein