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    Cops7a COP9 signalosome subunit 7A [ Mus musculus (house mouse) ]

    Gene ID: 26894, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cops7aprovided by MGI
    Official Full Name
    COP9 signalosome subunit 7Aprovided by MGI
    Primary source
    MGI:MGI:1349400
    See related
    Ensembl:ENSMUSG00000030127 AllianceGenome:MGI:1349400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SGN7a; D6Ertd35e
    Summary
    Predicted to be involved in protein deneddylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Is expressed in several structures, including adipose tissue; brain; eye; genitourinary system; and gut. Orthologous to human COPS7A (COP9 signalosome subunit 7A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 98.1), adrenal adult (RPKM 67.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cops7a in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124935413..124974866, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124958445..124997903, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene STARR-seq mESC enhancer starr_17314 Neighboring gene predicted gene, 38896 Neighboring gene STARR-positive B cell enhancer ABC_E8969 Neighboring gene STARR-seq mESC enhancer starr_17317 Neighboring gene myeloid leukemia factor 2 Neighboring gene STARR-seq mESC enhancer starr_17318 Neighboring gene STARR-seq mESC enhancer starr_17319 Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene STARR-positive B cell enhancer ABC_E6488 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7). Dessau M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077498, Free PMC Article
    2. Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after gamma-irradiation in mice. Cui DX, et al. World J Gastroenterol, 2000 Oct. PMID 11819679, Free PMC Article
    3. Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome. Berse M, et al. J Mol Biol, 2004 Oct 15. PMID 15451666
    4. The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein. Zarich N, et al. Oncogenesis, 2019 Jan 4. PMID 30631038, Free PMC Article
    5. COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein. Liang E, et al. Neuropsychiatr Dis Treat, 2021. PMID 33911869, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This protein was purified to homogeneity and screened for crystallization.
      Title: Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in COP9 signalosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 7a
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 7a
    COP9 (constitutive photomorphogenic), subunit 7a
    COP9 complex S7a
    JAB1-containing signalosome subunit 7a
    signalosome subunit 7a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164089.3 → NP_001157561.1  COP9 signalosome complex subunit 7a isoform 2

      See identical proteins and their annotated locations for NP_001157561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate 5' UTR, and has a distinct 3' terminal exon and UTR, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1. Variants 2, 7-10, and 12 all encode the same isoform (2).
      Source sequence(s)
      AC164563
      Consensus CDS
      CCDS51909.1
      UniProtKB/TrEMBL
      D3Z440
      Related
      ENSMUSP00000108058.3, ENSMUST00000112439.9
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    2. NM_001355541.2 → NP_001342470.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164563
      Consensus CDS
      CCDS20539.1
      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    3. NM_001355542.2 → NP_001342471.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1, 3-6, and 11 all encode the same isoform (1).
      Source sequence(s)
      AC164563
      Consensus CDS
      CCDS20539.1
      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    4. NM_001379119.1 → NP_001366048.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    5. NM_001379120.1 → NP_001366049.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    6. NM_001379122.1 → NP_001366051.1  COP9 signalosome complex subunit 7a isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    7. NM_001379123.1 → NP_001366052.1  COP9 signalosome complex subunit 7a isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    8. NM_001379124.1 → NP_001366053.1  COP9 signalosome complex subunit 7a isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    9. NM_001379125.1 → NP_001366054.1  COP9 signalosome complex subunit 7a isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/TrEMBL
      D3Z440
      Related
      ENSMUSP00000117584.2, ENSMUST00000129976.8
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    10. NM_001410594.1 → NP_001397523.1  COP9 signalosome complex subunit 7a isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164563
      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04

    11. NM_001410595.1 → NP_001397524.1  COP9 signalosome complex subunit 7a isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164563

    12. NM_012003.4 → NP_036133.1  COP9 signalosome complex subunit 7a isoform 1

      See identical proteins and their annotated locations for NP_036133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 3-6, and 11 all encode the same isoform (1).
      Source sequence(s)
      AC164563
      Consensus CDS
      CCDS20539.1
      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
      UniProtKB/TrEMBL
      D3Z440
      Related
      ENSMUSP00000032220.9, ENSMUST00000032220.15
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124935413..124974866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255406.2 → XP_030111266.1  COP9 signalosome complex subunit 7a isoform X2

      UniProtKB/Swiss-Prot
      O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
      UniProtKB/TrEMBL
      D3Z440
      Conserved Domains (2) summary
      smart00088
      Location:87 → 177
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam18392
      Location:166 → 215
      CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ04.2 GenPept UniProtKB/Swiss-Prot:Q9CZ04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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