Trnau1ap tRNA selenocysteine 1 associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trnau1approvided by MGI
Official Full Name: tRNA selenocysteine 1 associated protein 1provided by MGI
Primary source: MGI:MGI:1919037
See related: Ensembl:ENSMUSG00000028898 AllianceGenome:MGI:1919037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Secp43; Trspap1; 1110007F05Rik; WI1-2643G14.2
Summary: Predicted to enable tRNA binding activity. Involved in selenocysteine incorporation. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human TRNAU1AP (tRNA selenocysteine 1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 7.1), CNS E11.5 (RPKM 6.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 65.16 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132039074..132058007, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132311763..132330696, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of Trnau1ap reduced cell migration and proliferation. Knockdown of Trnau1ap blocked the PI3K/Akt signaling pathway.
Title: Knockdown of Trnau1ap inhibits the proliferation and migration of NIH3T3, JEG-3 and Bewo cells via the PI3K/Akt signaling pathway.
These findings suggest that the targeted domains in the SECp43 protein are not essential for selenoprotein biosynthesis in hepatocytes and neurons.
Title: Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).
SECp43 and SLA have roles in selenoprotein synthesis
Title: Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235049

NoName (e-PCR)
- UniSTS:235050

Trspap1 (e-PCR), detects polymorphism
- UniSTS:479050

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in selenocysteine incorporation	IBA Inferred from Biological aspect of Ancestor more info
involved_in selenocysteine incorporation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tRNA selenocysteine 1-associated protein 1

Names: tRNA selenocysteine-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027925.3 → NP_082201.2 tRNA selenocysteine 1-associated protein 1

See identical proteins and their annotated locations for NP_082201.2

Status: VALIDATED

Source sequence(s)

AK152986, BC099594, BY283216, CJ166630

Consensus CDS

CCDS18722.1

UniProtKB/Swiss-Prot

Q05DN9, Q4FZE9, Q7TMM7, Q80VC6

Related

ENSMUSP00000030730.8, ENSMUST00000030730.14

Conserved Domains (2) summary

cd12610
Location:4 → 87

RRM1_SECp43; RNA recognition motif 1 in tRNA selenocysteine-associated protein 1 (SECp43)

cd12612
Location:95 → 176

RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

132039074..132058007 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539180.4 → XP_006539243.1 tRNA selenocysteine 1-associated protein 1 isoform X1

Conserved Domains (2) summary

cd12612
Location:29 → 110

RRM2_SECp43; RNA recognition motif 2 in tRNA selenocysteine-associated protein 1 (SECp43)

pfam17654
Location:139 → 218

Trnau1ap; Selenocysteine tRNA 1 associated proteins
XM_011250332.3 → XP_011248634.1 tRNA selenocysteine 1-associated protein 1 isoform X2

See identical proteins and their annotated locations for XP_011248634.1

Related

ENSMUST00000146166.8

Conserved Domains (2) summary

pfam17654
Location:95 → 174

Trnau1ap; Selenocysteine tRNA 1 associated proteins

cl17169
Location:1 → 66

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011250334.3 → XP_011248636.1 tRNA selenocysteine 1-associated protein 1 isoform X2

See identical proteins and their annotated locations for XP_011248636.1

Conserved Domains (2) summary

pfam17654
Location:95 → 174

Trnau1ap; Selenocysteine tRNA 1 associated proteins

cl17169
Location:1 → 66

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030253783.2 → XP_030109643.1 tRNA selenocysteine 1-associated protein 1 isoform X2

Conserved Domains (2) summary

pfam17654
Location:95 → 174

Trnau1ap; Selenocysteine tRNA 1 associated proteins

cl17169
Location:1 → 66

RRM_SF; RNA recognition motif (RRM) superfamily
XM_017320388.3 → XP_017175877.1 tRNA selenocysteine 1-associated protein 1 isoform X2

Conserved Domains (2) summary

pfam17654
Location:95 → 174

Trnau1ap; Selenocysteine tRNA 1 associated proteins

cl17169
Location:1 → 66

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030253782.2 → XP_030109642.1 tRNA selenocysteine 1-associated protein 1 isoform X2

Conserved Domains (2) summary

pfam17654
Location:95 → 174

Trnau1ap; Selenocysteine tRNA 1 associated proteins

cl17169
Location:1 → 66

RRM_SF; RNA recognition motif (RRM) superfamily
XM_030253784.1 → XP_030109644.1 tRNA selenocysteine 1-associated protein 1 isoform X2

Conserved Domains (2) summary

pfam17654
Location:95 → 174

Trnau1ap; Selenocysteine tRNA 1 associated proteins

cl17169
Location:1 → 66

RRM_SF; RNA recognition motif (RRM) superfamily