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    Kctd14 potassium channel tetramerisation domain containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 233529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kctd14provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 14provided by MGI
    Primary source
    MGI:MGI:1289222
    See related
    Ensembl:ENSMUSG00000051727 AllianceGenome:MGI:1289222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Ertd760e
    Summary
    Is expressed in testis and urogenital ridge. Orthologous to human KCTD14 (potassium channel tetramerization domain containing 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 44.5), liver E14.5 (RPKM 6.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kctd14 in Genome Data Viewer
    Location:
    7 E1; 7 53.51 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (97085587..97108764)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (97436380..97459557)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19594 Neighboring gene thyroid hormone responsive Neighboring gene STARR-seq mESC enhancer starr_19596 Neighboring gene predicted gene, 32945 Neighboring gene STARR-positive B cell enhancer ABC_E4950 Neighboring gene integrator complex subunit 4 Neighboring gene predicted gene, 24412 Neighboring gene adipogenesis associated Mth938 domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WT1-mediated gene regulation in early urogenital ridge development. Klattig J, et al. Sex Dev, 2007. PMID 18391535
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD14
    Names
    potassium channel tetramerization domain containing 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010826.3 → NP_001010826.2  BTB/POZ domain-containing protein KCTD14 isoform b

      See identical proteins and their annotated locations for NP_001010826.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that has a distinct N-terminus and is shorter than isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC172193, AK145279, BY735425, CK791017, EH106497
      Consensus CDS
      CCDS85342.1
      UniProtKB/TrEMBL
      Q5EER8
      Related
      ENSMUSP00000145727.2, ENSMUST00000205577.2
      Conserved Domains (1) summary
      cl38908
      Location:19 → 115
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. NM_001012434.3 → NP_001012436.1  BTB/POZ domain-containing protein KCTD14 isoform b

      See identical proteins and their annotated locations for NP_001012436.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that has a distinct N-terminus and is shorter than isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC172193, BY735425, CK791017, EH106497
      Consensus CDS
      CCDS85342.1
      UniProtKB/TrEMBL
      Q5EER8
      Related
      ENSMUSP00000060557.8, ENSMUST00000050732.14
      Conserved Domains (1) summary
      cl38908
      Location:19 → 115
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    3. NM_001136235.1 → NP_001129707.1  BTB/POZ domain-containing protein KCTD14 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC172193, BG088171, EH106497
      Consensus CDS
      CCDS21459.2
      UniProtKB/TrEMBL
      A0A0U1RNG7
      Related
      ENSMUSP00000145558.2, ENSMUST00000206658.2
      Conserved Domains (2) summary
      smart00225
      Location:73 → 163
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cl02518
      Location:73 → 153
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      97085587..97108764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507607.3 → XP_006507670.2  BTB/POZ domain-containing protein KCTD14 isoform X1

      Conserved Domains (1) summary
      cl38908
      Location:96 → 192
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_006507610.3 → XP_006507673.1  BTB/POZ domain-containing protein KCTD14 isoform X3

      UniProtKB/TrEMBL
      A0A0U1RPG8
      Related
      ENSMUSP00000145977.2, ENSMUST00000206279.2
      Conserved Domains (1) summary
      cl38908
      Location:51 → 147
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    3. XM_006507608.3 → XP_006507671.1  BTB/POZ domain-containing protein KCTD14 isoform X2

      See identical proteins and their annotated locations for XP_006507671.1

      UniProtKB/TrEMBL
      Q5EER8
      Conserved Domains (1) summary
      cl38908
      Location:19 → 115
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    4. XM_030242478.2 → XP_030098338.1  BTB/POZ domain-containing protein KCTD14 isoform X2

      UniProtKB/TrEMBL
      Q5EER8
      Conserved Domains (1) summary
      cl38908
      Location:19 → 115
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    5. XM_006507609.3 → XP_006507672.1  BTB/POZ domain-containing protein KCTD14 isoform X2

      See identical proteins and their annotated locations for XP_006507672.1

      UniProtKB/TrEMBL
      Q5EER8
      Conserved Domains (1) summary
      cl38908
      Location:19 → 115
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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