Slc1a4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc1a4provided by MGI
Official Full Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4provided by MGI
Primary source: MGI:MGI:2135601
See related: Ensembl:ENSMUSG00000020142 AllianceGenome:MGI:2135601
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SATT; ASCT1; ASCT-1
Summary: Enables L-aspartate transmembrane transporter activity; L-serine transmembrane transporter activity; and neutral L-amino acid transmembrane transporter activity. Involved in L-aspartate import across plasma membrane. Acts upstream of or within serine import across plasma membrane. Located in intermediate filament. Is expressed in several structures, including central nervous system; dorsal root ganglion; lung; nose; and thymus primordium. Used to study spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Human ortholog(s) of this gene implicated in spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to human SLC1A4 (solute carrier family 1 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 12.1), whole brain E14.5 (RPKM 9.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 12.97 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (20252180..20282713, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (20302180..20332713, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
Title: Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's Disease.
Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex.
Title: Air pollution exposure increases ABCB1 and ASCT1 transporter levels in mouse cortex.
The ability of L-4FPG to penetrate the brain makes this compound a useful tool to further evaluate the function of ASCT1 and ASCT2 transporters in the CNS.
Title: Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction.
ASCT1, rather than ASCT2, is a component of the brain serine shuttle. ASCT1-KO mice display motor and neurodevelopmental deficits reminiscent of ASCT1 missense mutations in humans.
Title: ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment.
Results demonstrate injury-induced changes in Phgdh and ASCT1 expression.
Title: Expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase (Phgdh) and neutral amino acid transporter ASCT1 following an excitotoxic lesion in the mouse hippocampus.
ASCT1 expression was gradually downregulated in neuronal populations during late embryonic and neonatal periods, whereas its high expression was transmitted to radial glial cells and then to astrocytes; ASCT1 appears regulated to meet metabolic demands
Title: Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries.
results strongly suggest that combinations of amino acid sequence changes and N-linked oligosaccharides in a critical carboxyl-terminal region of extracellular loop 2 (ECL2) control retroviral utilization of both the ASCT1 and ASCT2 receptors
Title: N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions.
used as receptor by HERV-W Env glycoprotein when their sites for N-glycosylation are eliminated by mutagenesis
Title: The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.
either Phgdh or ASCT1 is provided to each segment of renal tubules, suggesting that metabolic interplay mediated by L-serine biosynthesis and supply may exist in the kidney
Title: Segmental and complementary expression of L-serine biosynthetic enzyme 3-phosphoglycerate dehydrogenase and neutral amino acid transporter ASCT1 in the mouse kidney.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SLC1A4 (e-PCR)
- UniSTS:513655

AW045657 (e-PCR)
- UniSTS:180161

Slc1a4 (e-PCR), detects polymorphism
- UniSTS:547317

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-cystine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-cystine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-hydroxyproline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-hydroxyproline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-proline transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-proline transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-serine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-serine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-threonine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-threonine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-threonine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-alanine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-cystine transport	IEA Inferred from Electronic Annotation more info
involved_in L-cystine transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-serine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-serine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine transport	ISO Inferred from Sequence Orthology more info
involved_in acidic amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in hydroxyproline transport	IEA Inferred from Electronic Annotation more info
involved_in hydroxyproline transport	ISO Inferred from Sequence Orthology more info
involved_in proline transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within serine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in threonine transport	IEA Inferred from Electronic Annotation more info
involved_in threonine transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neutral amino acid transporter A

Names: alanine/serine/cysteine/threonine transporter 1; solute carrier family 1 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428788.1 → NP_001415717.1 neutral amino acid transporter A isoform 2

Status: VALIDATED

Source sequence(s)

AL662926
NM_018861.4 → NP_061349.3 neutral amino acid transporter A isoform 1

See identical proteins and their annotated locations for NP_061349.3

Status: VALIDATED

Source sequence(s)

AL662926

Consensus CDS

CCDS24457.1

UniProtKB/Swiss-Prot

O35874

UniProtKB/TrEMBL

Q3US35, Q3UTP8, Q8BXT5, Q9ESU8

Related

ENSMUSP00000105223.2, ENSMUST00000109594.8

Conserved Domains (1) summary

pfam00375
Location:44 → 477

SDF; Sodium:dicarboxylate symporter family