Cavin2 caveolae associated 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cavin2provided by MGI
Official Full Name: caveolae associated 2provided by MGI
Primary source: MGI:MGI:99513
See related: Ensembl:ENSMUSG00000045954 AllianceGenome:MGI:99513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sdpr
Summary: Predicted to enable phosphatidylserine binding activity and protein kinase C binding activity. Predicted to be involved in plasma membrane tubulation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in several cellular components, including cytosol; membrane raft; and nucleoplasm. Predicted to be active in caveola and cytoplasm. Is expressed in several structures, including dorsal root ganglion; embryo mesenchyme; genitourinary system; sensory organ; and tongue. Orthologous to human CAVIN2 (caveolae associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 123.4), subcutaneous fat pad adult (RPKM 70.9) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 26.13 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (51328285..51342119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (51289126..51302960)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cavin-2 promotes fibroblast-to-myofibroblast trans-differentiation and aggravates cardiac fibrosis.
Title: Cavin-2 promotes fibroblast-to-myofibroblast trans-differentiation and aggravates cardiac fibrosis.
Requirement of Cavin-2 for the expression and stability of IRbeta in adequate adipocyte differentiation.
Title: Requirement of Cavin-2 for the expression and stability of IRβ in adequate adipocyte differentiation.
results indicate that in addition to its function in caveolae biogenesis, Cavin-2 plays a critical role in endothelial cell maintenance and function by regulating eNOS activity.
Title: Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis.
The roles of cavins 2 and 3 in caveolar morphogenesis in vivo, are reported.
Title: Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19367 (e-PCR)
- UniSTS:124809

NoName (e-PCR)
- UniSTS:547539

Sdpr (e-PCR), detects polymorphism
- UniSTS:547539

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in plasma membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane tubulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in caveola	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caveolae-associated protein 2

Names: cavin-2; phosphatidylserine-binding protein; serum deprivation response; serum deprivation-response protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.