Sqle squalene epoxidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sqleprovided by MGI
Official Full Name: squalene epoxidaseprovided by MGI
Primary source: MGI:MGI:109296
See related: Ensembl:ENSMUSG00000022351 AllianceGenome:MGI:109296
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable FAD binding activity and squalene monooxygenase activity. Predicted to be involved in several processes, including lipid droplet formation; response to biphenyl; and sterol metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human SQLE (squalene epoxidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 52.8), whole brain E14.5 (RPKM 35.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 25.16 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (59186941..59203042)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (59315092..59331193)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer.
Title: Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer.
Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
Title: Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis.
Title: Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis.
results demonstrate critical dependence of a 205 bp region for sterol dependent regulation of squalene epoxidase & uncover a possible framework for SREBP-promoter interaction, including a potent synergy with NF-Y that may be of principal importance.
Title: Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y.
Squalene epoxidase is a strong positional candidate gene for obesity, using squantitative trait locus studies.
Title: Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways.
Requires a redox partner, but cytochrome p450 reductase is not the only microsomal reductase that will serve this purpose.
Title: Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI323792 (e-PCR)
- UniSTS:165929

Sqle (e-PCR), detects polymorphism
- UniSTS:547152

Sqle (e-PCR), detects polymorphism
- UniSTS:144505

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables squalene monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables squalene monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables squalene monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to biphenyl	IEA Inferred from Electronic Annotation more info
involved_in response to biphenyl	ISO Inferred from Sequence Orthology more info
involved_in sterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in sterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: squalene monooxygenase

Names: SE

NP_033296.1

EC 1.14.14.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009270.3 → NP_033296.1 squalene monooxygenase

See identical proteins and their annotated locations for NP_033296.1

Status: PROVISIONAL

Source sequence(s)

AC113269

Consensus CDS

CCDS27497.1

UniProtKB/Swiss-Prot

P52019

UniProtKB/TrEMBL

Q3TQK8, Q3TSS7

Related

ENSMUSP00000022977.8, ENSMUST00000022977.14

Conserved Domains (2) summary

COG0654
Location:123 → 497

UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]

cl21454
Location:275 → 546

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins