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    Nagk N-acetylglucosamine kinase [ Mus musculus (house mouse) ]

    Gene ID: 56174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nagkprovided by MGI
    Official Full Name
    N-acetylglucosamine kinaseprovided by MGI
    Primary source
    MGI:MGI:1860418
    See related
    Ensembl:ENSMUSG00000034744 AllianceGenome:MGI:1860418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnk
    Summary
    Enables N-acetylglucosamine kinase activity; N-acylmannosamine kinase activity; and muramyl dipeptide kinase activity. Involved in positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Acts upstream of or within N-acetylglucosamine metabolic process. Is expressed in several structures, including eye; genitourinary system; liver; nervous system; and spleen. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.3), placenta adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nagk in Genome Data Viewer
    Location:
    6 C3; 6 35.96 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83770810..83779538)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83794983..83802556)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52907 Neighboring gene predicted gene, 53176 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene STARR-positive B cell enhancer mm9_chr6:83781714-83782015 Neighboring gene predicted gene, 23014

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Upregulation of dendritic arborization by N-acetyl-D-glucosamine kinase is not dependent on its kinase activity. Lee H, et al. Mol Cells, 2014 Apr. PMID 24722415, Free PMC Article
    2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance. Ripon MKH, et al. Cell Death Dis, 2020 Aug 14. PMID 32796833, Free PMC Article
    3. Molecular cloning and characterization of murine and human N-acetylglucosamine kinase. Hinderlich S, et al. Eur J Biochem, 2000 Jun. PMID 10824116
    4. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation. Stafford CA, et al. Nature, 2022 Sep. PMID 36002575, Free PMC Article
    5. Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Nabeshima R, et al. Elife, 2018 Aug 2. PMID 30070635, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
      Title: Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.
    2. N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
      Title: N-acetyl-D-glucosamine kinase binds dynein light chain roadblock 1 and promotes protein aggregate clearance.
    3. small domain, and not kinase activity, promotes dendritogenesis
      Title: Upregulation of dendritic arborization by N-acetyl-D-glucosamine kinase is not dependent on its kinase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylglucosamine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acylmannosamine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables muramyl dipeptide kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables muramyl dipeptide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyl-D-glucosamine kinase
    Names
    GlcNAc kinase
    N-acetyl-D-mannosamine kinase
    muramyl dipeptide kinase
    NP_001157659.1
    NP_001334244.2
    NP_001398209.1
    NP_001398210.1
    NP_001398211.1
    NP_001398212.1
    NP_001398213.1
    NP_001398214.1
    NP_001398215.1
    NP_001398216.1
    NP_001398217.1
    NP_001398218.1
    NP_001398219.1
    NP_001398220.1
    NP_062415.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164187.2 → NP_001157659.1  N-acetyl-D-glucosamine kinase isoform 2

      See identical proteins and their annotated locations for NP_001157659.1

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283
      UniProtKB/TrEMBL
      Q9D997
      Related
      ENSMUST00000146117.8
      Conserved Domains (1) summary
      cl17037
      Location:2 → 228
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001347315.2 → NP_001334244.2  N-acetyl-D-glucosamine kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283
      Consensus CDS
      CCDS85072.1
      UniProtKB/TrEMBL
      Q9D997
      Related
      ENSMUSP00000109482.2, ENSMUST00000113851.8

    3. NM_001411280.1 → NP_001398209.1  N-acetyl-D-glucosamine kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283
      UniProtKB/TrEMBL
      Q9D997

    4. NM_001411281.1 → NP_001398210.1  N-acetyl-D-glucosamine kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283
      UniProtKB/TrEMBL
      Q9D997

    5. NM_001411282.1 → NP_001398211.1  N-acetyl-D-glucosamine kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283
      UniProtKB/TrEMBL
      Q9D997

    6. NM_001411283.1 → NP_001398212.1  N-acetyl-D-glucosamine kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    7. NM_001411284.1 → NP_001398213.1  N-acetyl-D-glucosamine kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    8. NM_001411285.1 → NP_001398214.1  N-acetyl-D-glucosamine kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    9. NM_001411286.1 → NP_001398215.1  N-acetyl-D-glucosamine kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    10. NM_001411287.1 → NP_001398216.1  N-acetyl-D-glucosamine kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    11. NM_001411288.1 → NP_001398217.1  N-acetyl-D-glucosamine kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    12. NM_001411289.1 → NP_001398218.1  N-acetyl-D-glucosamine kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    13. NM_001411290.1 → NP_001398219.1  N-acetyl-D-glucosamine kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    14. NM_001411291.1 → NP_001398220.1  N-acetyl-D-glucosamine kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    15. NM_019542.3 → NP_062415.1  N-acetyl-D-glucosamine kinase isoform 1

      See identical proteins and their annotated locations for NP_062415.1

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283
      Consensus CDS
      CCDS20286.1
      UniProtKB/Swiss-Prot
      Q9QZ08
      UniProtKB/TrEMBL
      Q3U2G9, Q9D997
      Related
      ENSMUSP00000042026.8, ENSMUST00000037376.14
      Conserved Domains (1) summary
      cl17037
      Location:1 → 279
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. NR_177202.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    2. NR_177203.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    3. NR_177204.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090647, AC156283

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83770810..83779538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004933610.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZ08.3 GenPept UniProtKB/Swiss-Prot:Q9QZ08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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