Trp53inp1 transformation related protein 53 inducible nuclear protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trp53inp1provided by MGI
Official Full Name: transformation related protein 53 inducible nuclear protein 1provided by MGI
Primary source: MGI:MGI:1926609
See related: Ensembl:ENSMUSG00000028211 AllianceGenome:MGI:1926609
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SIP; Teap; SIP18; SIP27; Stinp; Tp53inp1; p53DINP1; 2700057G22Rik
Summary: Enables antioxidant activity. Involved in several processes, including negative regulation of fibroblast proliferation; negative regulation of myofibroblast differentiation; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to ethanol; cellular response to hydroperoxide; and cellular response to methyl methanesulfonate. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study abdominal obesity-metabolic syndrome 1. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in thymus adult (RPKM 22.3), placenta adult (RPKM 6.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 5.03 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (11156441..11174379)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (11156441..11174379)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TP53INP1 plays a role in regulating muscle function and bioenergetics through oxidative capacity impairment possibly as the consequence of abnormal mitochondrial respiration regulation and/or defective blood supply.
Title: Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo.
Knockout of miR-155 in cardiac fibroblasts improves cardiac remodeling by targeting TP53INP1.
Title: MiR-155 Knockout in Fibroblasts Improves Cardiac Remodeling by Targeting Tumor Protein p53-Inducible Nuclear Protein 1.
These data provide evidence that the TP53INP1 gene prevents metabolic syndrome, through a mechanism involving prevention of oxidative stress by mitochondrial homeostasis regulation.
Title: Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.
Nanog enhances miR-17/92 cluster expression that in turn targets Trp53inp1, thus contributing to release neural stem cell self-renewal constraints.
Title: microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1.
TP53INP1 loss of expression contributes to pancreatic cancer formation in a conditional KrasG12D mouse model.
Title: Oxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreas.
these data emphasize the role of TP53INP1 in protection against cell injury
Title: Absence of tumor suppressor tumor protein 53-induced nuclear protein 1 (TP53INP1) sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis.
Tumor protein 53-induced nuclear protein 1 is a potential target for the prevention of colorectal cancer in patients with inflammatory bowel disease[Tumor protein 53-induced nuclear protein 1]
Title: Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.
TP53INP1s are functionally associated with p73 to regulate cell cycle progression and apoptosis.
Title: TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity.
Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53.
Title: P53-dependent expression of the stress-induced protein (SIP).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trp53inp1 (e-PCR), detects polymorphism
- UniSTS:507290

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagic cell death	ISO Inferred from Sequence Orthology more info
involved_in autophagic cell death	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to ethanol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to hydroperoxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to methyl methanesulfonate	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myofibroblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor protein p53-inducible nuclear protein 1

Names: p53-dependent damage-inducible nuclear protein 1; stress induced protein; thymus-expressed acidic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199105.2 → NP_001186034.1 tumor protein p53-inducible nuclear protein 1 isoform 2

See identical proteins and their annotated locations for NP_001186034.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional exon in the coding region which results in a frameshift and early stop codon, compared to variant 1. It encodes a shorter isoform (2; also known as SIP18) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL840625

UniProtKB/Swiss-Prot

Q9QXE4

Related

ENSMUST00000132010.8

Conserved Domains (1) summary

pfam14839
Location:24 → 158

DOR; DOR family
NM_021897.4 → NP_068697.1 tumor protein p53-inducible nuclear protein 1 isoform 1

See identical proteins and their annotated locations for NP_068697.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1; also known as SIP27).

Source sequence(s)

AL840625

Consensus CDS

CCDS17964.1

UniProtKB/Swiss-Prot

Q923I6, Q9QXE4

UniProtKB/TrEMBL

Q3UQK9

Related

ENSMUSP00000029865.4, ENSMUST00000029865.4

Conserved Domains (1) summary

pfam14839
Location:24 → 230

DOR; DOR family