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    Trmt12 tRNA methyltransferase 12 [ Mus musculus (house mouse) ]

    Gene ID: 68260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt12provided by MGI
    Official Full Name
    tRNA methyltransferase 12provided by MGI
    Primary source
    MGI:MGI:1915510
    See related
    Ensembl:ENSMUSG00000037085 AllianceGenome:MGI:1915510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tyw2; 4632406N01Rik
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human TRMT12 (tRNA methyltransferase 12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Trmt12 in Genome Data Viewer
    Location:
    15 D1; 15 25.09 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58744498..58748630)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58872649..58876781)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41329 Neighboring gene transmembrane protein 65 Neighboring gene STARR-positive B cell enhancer ABC_E5480 Neighboring gene predicted gene, 24041 Neighboring gene STARR-positive B cell enhancer ABC_E3141 Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene predicted gene, 36509 Neighboring gene ring finger protein 139 Neighboring gene TatD DNase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA wybutosine-synthesizing protein 2 homolog
    Names
    alpha-amino-alpha-carboxypropyl transferase TYW2
    tRNA methyltranferase 12 homolog
    tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
    tRNA-yW-synthesizing protein 2
    NP_080918.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026642.2 → NP_080918.2  tRNA wybutosine-synthesizing protein 2 homolog

      See identical proteins and their annotated locations for NP_080918.2

      Status: VALIDATED

      Source sequence(s)
      AC107772
      Consensus CDS
      CCDS37081.1
      UniProtKB/Swiss-Prot
      Q0P5W5, Q7TNQ8, Q8BG71, Q9D2N1
      Related
      ENSMUSP00000047831.8, ENSMUST00000036937.9
      Conserved Domains (2) summary
      COG0270
      Location:228 → 313
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      pfam02475
      Location:122 → 324
      Met_10; Met-10+ like-protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      58744498..58748630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG71.1 GenPept UniProtKB/Swiss-Prot:Q8BG71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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