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    Spaca9 sperm acrosome associated 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spaca9provided by RGD
    Official Full Name
    sperm acrosome associated 9provided by RGD
    Primary source
    RGD:727909
    See related
    EnsemblRapid:ENSRNOG00000012697 AllianceGenome:RGD:727909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rsb66
    Summary
    Predicted to enable calcium-dependent protein binding activity and microtubule binding activity. Predicted to be involved in axoneme assembly. Located in cytoplasm and nucleus. Orthologous to human SPACA9 (sperm acrosome associated 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 110.9) and Lung (RPKM 20.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spaca9 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32417350..32426776, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (12019376..12028801, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7269851..7279253, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene growth factor independent 1B transcriptional repressor Neighboring gene TSC complex subunit 1 Neighboring gene adenylate kinase 8 Neighboring gene RNA, U1 small nuclear 136

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). Chen X, et al. Biochem Cell Biol, 2008 Aug. PMID 18756329
    2. A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome. Bhattacharya R, et al. BMC Cell Biol, 2013 Nov 20. PMID 24256100, Free PMC Article
    3. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
    4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    5. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC114240

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in axonemal microtubule doublet inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axonemal microtubule doublet inner sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome-associated protein 9
    Names
    Rsb-66 protein
    uncharacterized protein C9orf9 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401818.1 → NP_001388747.1  sperm acrosome-associated protein 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A8T2
      Related
      ENSRNOP00000088937.1, ENSRNOT00000120222.2
      Conserved Domains (1) summary
      pfam15120
      Location:2 → 165
      SPACA9; Sperm acrosome-associated protein 9

    2. NM_181694.3 → NP_859045.2  sperm acrosome-associated protein 9 isoform 2

      See identical proteins and their annotated locations for NP_859045.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q4V8P4, Q7TSB9
      Conserved Domains (1) summary
      pfam15120
      Location:2 → 165
      SPACA9; Sperm acrosome-associated protein 9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      32417350..32426776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233766.4 → XP_006233828.1  sperm acrosome-associated protein 9 isoform X3

      See identical proteins and their annotated locations for XP_006233828.1

      UniProtKB/TrEMBL
      A0A8L2Q9C4, A6JTP7
      Related
      ENSRNOP00000017004.3, ENSRNOT00000017004.4
      Conserved Domains (1) summary
      pfam15120
      Location:43 → 205
      DUF4561; Domain of unknown function (DUF4561)

    2. XM_063283481.1 → XP_063139551.1  sperm acrosome-associated protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GL53
      Related
      ENSRNOP00000095426.1, ENSRNOT00000112266.2

    3. XM_063283482.1 → XP_063139552.1  sperm acrosome-associated protein 9 isoform X4

      UniProtKB/Swiss-Prot
      Q4V8P4, Q7TSB9

    4. XM_017591644.3 → XP_017447133.1  sperm acrosome-associated protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8T2
      Conserved Domains (1) summary
      pfam15120
      Location:2 → 165
      SPACA9; Sperm acrosome-associated protein 9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8P4.1 GenPept UniProtKB/Swiss-Prot:Q4V8P4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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