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    Bnipl BCL2 interacting protein like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361994, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Bniplprovided by RGD
    Official Full Name
    BCL2 interacting protein likeprovided by RGD
    Primary source
    RGD:1309478
    See related
    EnsemblRapid:ENSRNOG00000021116 AllianceGenome:RGD:1309478
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of growth rate. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol and nucleus. Orthologous to human BNIPL (BCL2 interacting protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 11.2), Thymus (RPKM 6.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bnipl in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185507591..185519415, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182818593..182830421, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196415736..196425727, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CDC42 small effector 1 Neighboring gene similar to human chromosome 1 open reading frame 56 Neighboring gene prune exopolyphosphatase 1 Neighboring gene MINDY lysine 48 deubiquitinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER. Shen L, et al. FEBS Lett, 2003 Apr 10. PMID 12681488
    2. The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence. Zhou YT, et al. J Biol Chem, 2002 Mar 1. PMID 11741952
    3. BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. Qin W, et al. Biochem Biophys Res Commun, 2003 Aug 22. PMID 12901880
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC188483

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of growth rate ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
    Names
    BCL2/adenovirus E1B 19kD interacting protein like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128187.2 → NP_001121659.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

      See identical proteins and their annotated locations for NP_001121659.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166747
      UniProtKB/TrEMBL
      A6K2X6, B2RYE3, F7FCQ2
      Related
      ENSRNOP00000028671.5, ENSRNOT00000028671.7
      Conserved Domains (2) summary
      pfam12496
      Location:82 → 210
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:212 → 337
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185507591..185519415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102695.1 → XP_038958623.1  bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein isoform X1

      Conserved Domains (2) summary
      pfam12496
      Location:102 → 230
      BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
      pfam13716
      Location:232 → 369
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    Nucleotide Protein Strain
    Heading Accession and Version

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