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    Myl12a myosin, light chain 12A, regulatory, non-sarcomeric [ Mus musculus (house mouse) ]

    Gene ID: 67268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myl12aprovided by MGI
    Official Full Name
    myosin, light chain 12A, regulatory, non-sarcomericprovided by MGI
    Primary source
    MGI:MGI:1914518
    See related
    Ensembl:ENSMUSG00000024048 AllianceGenome:MGI:1914518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900073G15Rik
    Summary
    Enables glutamate receptor binding activity. Acts upstream of or within protein localization to plasma membrane and regulation of cell shape. Located in Z disc and stress fiber. Part of myosin II complex. Orthologous to human MYL12A (myosin light chain 12A) and MYL12B (myosin light chain 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 191.4), heart adult (RPKM 159.8) and 28 other tissues See more
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    Genomic context

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    See Myl12a in Genome Data Viewer
    Location:
    17 E1.3; 17 41.87 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71300788..71309528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (70993793..71002533, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46595 Neighboring gene STARR-positive B cell enhancer mm9_chr17:71323576-71323876 Neighboring gene predicted gene, 41611 Neighboring gene STARR-seq mESC enhancer starr_43170 Neighboring gene myosin, light chain 12B, regulatory Neighboring gene STARR-positive B cell enhancer ABC_E3214 Neighboring gene predicted gene, 53974 Neighboring gene myomesin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. Höpker K, et al. EMBO J, 2012 Oct 17. PMID 22909821, Free PMC Article
    2. N-methyl-D-aspartate receptor subunits are non-myosin targets of myosin regulatory light chain. Bajaj G, et al. J Biol Chem, 2009 Jan 9. PMID 18945678, Free PMC Article
    3. Stage-dependent function of Wnt5a during male external genitalia development. Alcantara MC, et al. Congenit Anom (Kyoto), 2021 Nov. PMID 34255394
    4. Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction. Sun J, et al. Front Physiol, 2020. PMID 33424621, Free PMC Article
    5. Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis. Tang YC, et al. Cell Rep, 2023 Mar 28. PMID 36871220

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin light chain, regulatory B-like
    Names
    NMDA receptor-interacting protein
    brain specific myosin regulatory light chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357820.1 → NP_001344749.1  myosin light chain, regulatory B-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154187, AI838292, BF661452, DV063953
      UniProtKB/TrEMBL
      Q9D6E6
      Conserved Domains (1) summary
      COG5126
      Location:25 → 175
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. NM_026064.2 → NP_080340.2  myosin light chain, regulatory B-like isoform 1

      See identical proteins and their annotated locations for NP_080340.2

      Status: VALIDATED

      Source sequence(s)
      AK045160, BY258797, BY319676, CAAA01075437
      Consensus CDS
      CCDS28955.1
      UniProtKB/TrEMBL
      Q6ZWQ9, Q9D6E6
      Related
      ENSMUSP00000123412.2, ENSMUST00000148960.8
      Conserved Domains (1) summary
      COG5126
      Location:19 → 169
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      71300788..71309528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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