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    Zfp426 zinc finger protein 426 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690895, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp426provided by RGD
    Official Full Name
    zinc finger protein 426provided by RGD
    Primary source
    RGD:1590942
    See related
    EnsemblRapid:ENSRNOG00000033624 AllianceGenome:RGD:1590942
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf426
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF426 (zinc finger protein 426). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 46.5), Spleen (RPKM 42.9) and 9 other tissues See more
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    Genomic context

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    See Zfp426 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (27272830..27305116, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (18996583..19029266, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (21477328..21511228, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 560 Neighboring gene zinc finger protein 26 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 266 Neighboring gene ribosomal protein SA, pseudogene 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156802

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 426

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079943.1 → NP_001073412.1  zinc finger protein 426

      See identical proteins and their annotated locations for NP_001073412.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129125
      UniProtKB/Swiss-Prot
      A1L1L7
      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:331 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:222 → 244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:291 → 316
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      27272830..27305116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266170.1 → XP_063122240.1  zinc finger protein 426 isoform X4

      UniProtKB/TrEMBL
      A0A8L2R1Q2

    2. XM_063266164.1 → XP_063122234.1  zinc finger protein 426 isoform X2

    3. XM_063266169.1 → XP_063122239.1  zinc finger protein 426 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZP77, A6JNI8
      Related
      ENSRNOP00000079954.1, ENSRNOT00000095440.2

    4. XM_017595918.3 → XP_017451407.1  zinc finger protein 426 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:331 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:222 → 244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:291 → 316
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063266168.1 → XP_063122238.1  zinc finger protein 426 isoform X4

      UniProtKB/TrEMBL
      A0A8L2R1Q2

    6. XM_039082171.2 → XP_038938099.1  zinc finger protein 426 isoform X2

      Related
      ENSRNOP00000069966.3, ENSRNOT00000077465.3
      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:331 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:222 → 244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:291 → 316
      zf-H2C2_2; Zinc-finger double domain

    7. XM_063266162.1 → XP_063122232.1  zinc finger protein 426 isoform X1

      UniProtKB/Swiss-Prot
      A1L1L7

    8. XM_006242670.4 → XP_006242732.1  zinc finger protein 426 isoform X1

      See identical proteins and their annotated locations for XP_006242732.1

      UniProtKB/Swiss-Prot
      A1L1L7
      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:331 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:222 → 244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:291 → 316
      zf-H2C2_2; Zinc-finger double domain

    9. XM_063266171.1 → XP_063122241.1  zinc finger protein 426 isoform X5

      Related
      ENSRNOP00000038875.5, ENSRNOT00000038069.6

    10. XM_039082172.2 → XP_038938100.1  zinc finger protein 426 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZP77, A6JNI8
      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:330 → 482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:290 → 315
      zf-H2C2_2; Zinc-finger double domain

    11. XM_063266165.1 → XP_063122235.1  zinc finger protein 426 isoform X1

      UniProtKB/Swiss-Prot
      A1L1L7

    12. XM_063266163.1 → XP_063122233.1  zinc finger protein 426 isoform X2

      Related
      ENSRNOP00000084731.2, ENSRNOT00000117071.2

    13. XM_006242668.5 → XP_006242730.1  zinc finger protein 426 isoform X1

      See identical proteins and their annotated locations for XP_006242730.1

      UniProtKB/Swiss-Prot
      A1L1L7
      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:331 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:222 → 244
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:291 → 316
      zf-H2C2_2; Zinc-finger double domain

    14. XM_039082173.2 → XP_038938101.1  zinc finger protein 426 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZP77, A6JNI8
      Conserved Domains (5) summary
      smart00349
      Location:40 → 97
      KRAB; krueppel associated box
      COG5048
      Location:330 → 482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:446 → 466
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:221 → 243
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:290 → 315
      zf-H2C2_2; Zinc-finger double domain

    15. XM_008765983.4 → XP_008764205.1  zinc finger protein 426 isoform X5

      See identical proteins and their annotated locations for XP_008764205.1

      Conserved Domains (6) summary
      smart00349
      Location:14 → 71
      KRAB; krueppel associated box
      COG5048
      Location:305 → 457
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:196 → 218
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:433 → 458
      zf-H2C2_2; Zinc-finger double domain

    16. XM_008765984.4 → XP_008764206.1  zinc finger protein 426 isoform X5

      See identical proteins and their annotated locations for XP_008764206.1

      Conserved Domains (6) summary
      smart00349
      Location:14 → 71
      KRAB; krueppel associated box
      COG5048
      Location:305 → 457
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:196 → 218
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:433 → 458
      zf-H2C2_2; Zinc-finger double domain

    17. XM_063266167.1 → XP_063122237.1  zinc finger protein 426 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L1L7.1 GenPept UniProtKB/Swiss-Prot:A1L1L7

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