H2ac25 H2A clustered histone 25 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H2ac25provided by RGD
Official Full Name: H2A clustered histone 25provided by RGD
Primary source: RGD:621437
See related: EnsemblRapid:ENSRNOG00000064520 AllianceGenome:RGD:621437
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H2a; Hist3h2a
Summary: Predicted to enable DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in UV-damage excision repair; heterochromatin formation; and nucleosome disassembly. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human H2AC25 (H2A clustered histone 25). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44233283..44234835)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (43733702..43735254)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45297603..45299155)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Akt-mediated H2A phosphorylation has an anti-apoptotic function in conditions of H2O2-induced oxidative stress in neurons and PC12 cells.
Title: Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons.
the results demonstrate that histone 2A stimulates glucose-6-phosphatase activity by permeabilizing the microsomal membrane.
Title: Histone 2A stimulates glucose-6-phosphatase activity by permeabilization of liver microsomes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141298 (e-PCR)
- UniSTS:223294

RH138964 (e-PCR)
- UniSTS:221050

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in UV-damage excision repair	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histone H2A type 3

Names: histone 2a; histone 3, H2a; histone cluster 3, H2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.