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    Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kdelr2provided by RGD
    Official Full Name
    KDEL endoplasmic reticulum protein retention receptor 2provided by RGD
    Primary source
    RGD:1304618
    See related
    AllianceGenome:RGD:1304618
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable KDEL sequence binding activity. Predicted to be involved in protein retention in ER lumen and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in cis-Golgi network and endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to human KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 267.4), Kidney (RPKM 226.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kdelr2 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16252424..16270737, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11138820..11157117, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13192452..13210758, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene Rac family small GTPase 1 Neighboring gene diacylglycerol lipase, beta Neighboring gene Grid2 interacting protein Neighboring gene uncharacterized LOC134481326

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequence of a second human KDEL receptor. Lewis MJ, et al. J Mol Biol, 1992 Aug 20. PMID 1325562
    2. A molecular specificity code for the three mammalian KDEL receptors. Raykhel I, et al. J Cell Biol, 2007 Dec 17. PMID 18086916, Free PMC Article
    3. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, et al. J Neurosci, 2009 May 27. PMID 19474315, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ER retention sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables KDEL sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables KDEL sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables KDEL sequence binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of protein localization in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of protein localization in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in COPI-coated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in COPI-coated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ER lumen protein-retaining receptor 2
    Names
    KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
    KDEL receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013122.2 → NP_001013140.1  ER lumen protein-retaining receptor 2

      See identical proteins and their annotated locations for NP_001013140.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q5U305
      UniProtKB/TrEMBL
      A6K1L0
      Conserved Domains (1) summary
      pfam00810
      Location:28 → 169
      ER_lumen_recept; ER lumen protein retaining receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16252424..16270737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271257.1 → XP_063127327.1  ER lumen protein-retaining receptor 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U305.1 GenPept UniProtKB/Swiss-Prot:Q5U305

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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