Exoc3l2 exocyst complex component 3-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exoc3l2provided by MGI
Official Full Name: exocyst complex component 3-like 2provided by MGI
Primary source: MGI:MGI:1921713
See related: Ensembl:ENSMUSG00000011263 AllianceGenome:MGI:1921713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm19857; 4933417E01Rik
Summary: Predicted to enable SNARE binding activity. Acts upstream of or within in utero embryonic development. Predicted to be part of exocyst. Is expressed in rete testis and tunica albuginea of testis. Orthologous to human EXOC3L2 (exocyst complex component 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 22.7), kidney adult (RPKM 13.1) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.92 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19197212..19230687)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19463287..19496762)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data describe a novel splice variant of murine Exoc3l2, termed Exoc3l2a and suggest a possible functional implications of the resulting domain excision from this isoform of EXOC3L2 based on structural similarities with its paralog EXOC3L3, which is implicated in tunneling nanotube formation.
Title: Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec.
exoc3l2 silencing inhibits VEGF receptor 2 phosphorylation and VEGFA-directed migration of cultured endothelial cells.
Title: Exocyst complex component 3-like 2 (EXOC3L2) associates with the exocyst complex and mediates directional migration of endothelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235611

RH129012 (e-PCR)
- UniSTS:212320

AU042655 (e-PCR)
- UniSTS:159605

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in exocyst localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: exocyst complex component 3-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370800.1 → NP_001357729.1 exocyst complex component 3-like protein 2

Status: VALIDATED

Source sequence(s)

AC149052

Consensus CDS

CCDS90173.1

UniProtKB/TrEMBL

D3YUP5

Related

ENSMUSP00000123025.3, ENSMUST00000137613.9

Conserved Domains (1) summary

cl19885
Location:215 → 742

Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

19197212..19230687

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028954.2: Suppressed sequence

Description

NM_028954.2: This RefSeq was temporarily suppressed because the CDS was partial compared to orthologous protein data, and there was a deletion that resulted in a frameshifted coding region.