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    RAB6A Ras-related small GTP-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819069, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAB6A
    Official Full Name
    Ras-related small GTP-binding family protein
    Primary source
    TAIR:AT2G44610
    Locus tag
    AT2G44610
    See related
    Araport:AT2G44610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAB6A; ATRABH1B; F16B22.10; RAB6
    Summary
    Encodes a GTP-binding protein with similarity to yeast YPT6 . RAB6 can complement the yeast YTP mutant.
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    Genomic context

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    See RAB6A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (18411424..18414153, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DYNAMIN-like 1D Neighboring gene uncharacterized protein Neighboring gene mitochondrial acyl carrier protein 1 Neighboring gene Galactose oxidase/kelch repeat superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rab-H1b is essential for trafficking of cellulose synthase and for hypocotyl growth in Arabidopsis thaliana. He M, et al. J Integr Plant Biol, 2018 Nov. PMID 29975455
    2. A small GTP-binding protein from Arabidopsis thaliana functionally complements the yeast YPT6 null mutant. Bednarek SY, et al. Plant Physiol, 1994 Feb. PMID 8159788, Free PMC Article
    3. AtRAB-H1b and AtRAB-H1c GTPases, homologues of the yeast Ypt6, target reporter proteins to the Golgi when expressed in Nicotiana tabacum and Arabidopsis thaliana. Johansen JN, et al. J Exp Bot, 2009. PMID 19454595
    4. Fluorescence lifetime imaging of interactions between Golgi tethering factors and small GTPases in plants. Osterrieder A, et al. Traffic, 2009 Aug. PMID 19490533
    5. Localization and domain characterization of Arabidopsis golgin candidates. Latijnhouwers M, et al. J Exp Bot, 2007. PMID 18182439

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential subcelluar locations and stability of AtRAB-H1b and AtRAB-H1c altered in their GTP and membrane binding capacity.
      Title: AtRAB-H1b and AtRAB-H1c GTPases, homologues of the yeast Ypt6, target reporter proteins to the Golgi when expressed in Nicotiana tabacum and Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130025.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall cellulose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within secretion by cell IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    colocalizes_with Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    Ras-related small GTP-binding family protein
    NP_181989.1
    • RAB6A; FUNCTIONS IN: protein binding, GTP binding; INVOLVED IN: secretion by cell; LOCATED IN: plasma membrane, membrane fraction; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Ras (InterPro:IPR013753), Ras small GTPase, Rab type (InterPro:IPR003579), Rab6-related (InterPro:IPR015600); BEST Arabidopsis thaliana protein match is: RAB GTPase homolog H1E (TAIR:AT5G10260.1); Has 26612 Blast hits to 26583 proteins in 727 species: Archae - 21; Bacteria - 159; Metazoa - 14143; Fungi - 3598; Plants - 2938; Viruses - 20; Other Eukaryotes - 5733 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18411424..18414153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130025.5 → NP_181989.1  Ras-related small GTP-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O80501
      UniProtKB/TrEMBL
      A0A178W0B3, A0A5S9X7A8
      Conserved Domains (1) summary
      cd01861
      Location:10 → 170
      Rab6; Rab GTPase family 6 (Rab6)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O80501.1

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