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    Ntsr2 neurotensin receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 18217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ntsr2provided by MGI
    Official Full Name
    neurotensin receptor 2provided by MGI
    Primary source
    MGI:MGI:108018
    See related
    Ensembl:ENSMUSG00000020591 AllianceGenome:MGI:108018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NT2R; NTR2; NTRL; NT-R-2
    Summary
    Enables G protein-coupled neurotensin receptor activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and regulation of membrane potential. Located in membrane. Orthologous to human NTSR2 (neurotensin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 70.4), cortex adult (RPKM 64.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ntsr2 in Genome Data Viewer
    Location:
    12 A1.1; 12 7.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16703477..16710223)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16653443..16660236)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31636 Neighboring gene predicted gene, 53741 Neighboring gene STARR-seq mESC enhancer starr_31639 Neighboring gene lipin 1 Neighboring gene STARR-seq mESC enhancer starr_31643 Neighboring gene STARR-positive B cell enhancer ABC_E11503 Neighboring gene STARR-seq mESC enhancer starr_31645 Neighboring gene gene regulated by estrogen in breast cancer protein Neighboring gene E2F transcription factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system. Botto JM, et al. FEBS Lett, 1997 Jan 3. PMID 9001400
    2. Identification of the receptor subtype involved in the analgesic effect of neurotensin. Dubuc I, et al. J Neurosci, 1999 Jan 1. PMID 9870978, Free PMC Article
    3. Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice. Bredeloux P, et al. Behav Brain Res, 2006 Dec 15. PMID 17074405
    4. Neurotensin type 2 receptor is involved in fear memory in mice. Yamauchi R, et al. J Neurochem, 2007 Sep. PMID 17697051
    5. Involvement of NTS2 receptors in stress-induced analgesia. Lafrance M, et al. Neuroscience, 2010 Mar 17. PMID 20035838

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that neurotensin receptor 2 expression remains constant throughout lifespan, and is predominantly expressed within glia.
      Title: Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan.
    2. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala identify and validate Ntsr2-expressing neurons as a putative 'Fear-Off' population.
      Title: Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala.
    3. endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors.
      Title: Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
    4. findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption
      Title: Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2.
    5. These data support the regulation of baseline prepulse inhibition, acoustic startle response and locomotor activity by endogenous neurotensin acting at the NT2 receptor.
      Title: Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activity.
    6. Ntsr2 receptor subtype is necessary for normal dopaminergic function.
      Title: Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice.
    7. NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.
      Title: Involvement of NTS2 receptors in stress-induced analgesia.
    8. These results suggest that Ntsr2 in astrocytes and neurons may have unique function like a modulation of fear memory in the mouse brain.
      Title: Neurotensin type 2 receptor is involved in fear memory in mice.
    9. Recycling ability depends on a single tyrosine residue
      Title: Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.
    10. increase in jump latency induced by stimulation of NTS2 receptors is mediated by the release of an endogenous opioid receptor ligand
      Title: Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled neurotensin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled neurotensin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neurotensin receptor type 2
    Names
    low affinity neurotensin receptor
    low-affinity levocabastine-sensitive neurotensin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361702.2 → NP_001348631.1  neurotensin receptor type 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122228
      Conserved Domains (2) summary
      cd14964
      Location:35 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 233
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001361703.2 → NP_001348632.1  neurotensin receptor type 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122228
      Consensus CDS
      CCDS88315.1
      UniProtKB/TrEMBL
      A0A1Y7VN85
      Related
      ENSMUSP00000152290.2, ENSMUST00000220892.2
      Conserved Domains (2) summary
      cd14964
      Location:35 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 233
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. NM_001412674.1 → NP_001399603.1  neurotensin receptor type 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122228
      UniProtKB/TrEMBL
      Q920Q5

    4. NM_001412675.1 → NP_001399604.1  neurotensin receptor type 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122228

    5. NM_008747.3 → NP_032773.2  neurotensin receptor type 2 isoform 1

      See identical proteins and their annotated locations for NP_032773.2

      Status: VALIDATED

      Source sequence(s)
      AC122228
      Consensus CDS
      CCDS36407.1
      UniProtKB/Swiss-Prot
      P70310, Q8VIF5
      UniProtKB/TrEMBL
      Q920Q5
      Related
      ENSMUSP00000106693.2, ENSMUST00000111064.3
      Conserved Domains (1) summary
      pfam00001
      Location:85 → 358
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_182023.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122228, AK081073
      Related
      ENSMUST00000222957.2

    2. NR_182024.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122228

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      16703477..16710223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70310.2 GenPept UniProtKB/Swiss-Prot:P70310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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