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    NBS1 nijmegen breakage syndrome 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821254, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NBS1
    Official Full Name
    nijmegen breakage syndrome 1
    Primary source
    TAIR:AT3G02680
    Locus tag
    AT3G02680
    See related
    Araport:AT3G02680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNBS1; F16B3.31; F16B3_31; nijmegen breakage syndrome 1
    Summary
    DNA repair and meiotic recombination protein, component of MRE11 complex with RAD50 and MRE11
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    Genomic context

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    See NBS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (576308..579562)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Glycine-rich protein family Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene NC domain-containing protein-like protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NBS1 plays a synergistic role with telomerase in the maintenance of telomeres in Arabidopsis thaliana. Najdekrova L, et al. BMC Plant Biol, 2012 Sep 17. PMID 22985462, Free PMC Article
    2. Characterization of the plant homolog of Nijmegen breakage syndrome 1: Involvement in DNA repair and recombination. Akutsu N, et al. Biochem Biophys Res Commun, 2007 Feb 9. PMID 17182003
    3. NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants. Waterworth WM, et al. Plant J, 2007 Oct. PMID 17672843
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NBS1 acts in concert with telomerase and plays a profound role in plant telomere renewal.
      Title: NBS1 plays a synergistic role with telomerase in the maintenance of telomeres in Arabidopsis thaliana.
    2. results suggest a novel role for AtNBS1 that is independent of AtATM-mediated signaling and functions in the very early stages of meiosis
      Title: NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_111136.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ionizing radiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Mre11 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nijmegen breakage syndrome 1
    NP_186917.2
    • nijmegen breakage syndrome 1 (NBS1); CONTAINS InterPro DOMAIN/s: SMAD/FHA domain (InterPro:IPR008984), Forkhead-associated (FHA) domain (InterPro:IPR000253); Has 164 Blast hits to 161 proteins in 63 species: Archae - 0; Bacteria - 2; Metazoa - 112; Fungi - 0; Plants - 40; Viruses - 0; Other Eukaryotes - 10 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      576308..579562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111136.3 → NP_186917.2  nijmegen breakage syndrome 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186917.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1YEB0, Q0H8D7, Q9M874
      UniProtKB/TrEMBL
      A0A178VFZ6
      Conserved Domains (3) summary
      COG1716
      Location:24 → 148
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:2 → 124
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08599
      Location:467 → 522
      Nbs1_C; DNA damage repair protein Nbs1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0H8D7.1

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