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    PAC1 20S proteasome alpha subunit C1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821774, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAC1
    Official Full Name
    20S proteasome alpha subunit C1
    Primary source
    TAIR:AT3G22110
    Locus tag
    AT3G22110
    See related
    Araport:AT3G22110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    20S proteasome alpha subunit C1; 20S PROTEASOME SUBUNIT PAC1
    Summary
    Encodes the alpha-3 subunit of 20s proteasome.
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    Genomic context

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    See PAC1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (7792549..7794262, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene ncRNA Neighboring gene cell wall-plasma membrane linker protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
    2. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
    3. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660
    4. Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. Book AJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516081, Free PMC Article
    5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113108.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome core complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of proteasome core complex, alpha-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    20S proteasome alpha subunit C1
    NP_188850.1
    • 20S proteasome alpha subunit C1 (PAC1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: response to cadmium ion, ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: N-terminal nucleophile aminohydrolases (Ntn hydrolases) superfamily protein (TAIR:AT4G15165.1); Has 7432 Blast hits to 7428 proteins in 553 species: Archae - 896; Bacteria - 261; Metazoa - 2465; Fungi - 1789; Plants - 945; Viruses - 0; Other Eukaryotes - 1076 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7792549..7794262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113108.5 → NP_188850.1  20S proteasome alpha subunit C1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23711, O81148
      UniProtKB/TrEMBL
      A0A178VJ65, A0A5S9XEH3, A0A5S9XSS7
      Conserved Domains (1) summary
      cd03752
      Location:3 → 215
      proteasome_alpha_type_4; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81148.1

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