GLR3.3 glutamate receptor 3.3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GLR3.3
Official Full Name: glutamate receptor 3.3
Primary source: TAIR:AT1G42540
Locus tag: AT1G42540
See related: Araport:AT1G42540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGLR3.3; glutamate receptor 3.3; T8D8.1; T8D8_1
Summary: member of Putative ligand-gated ion channel subunit family
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Genomic context

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See GLR3.3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (15973054..15976813)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The carboxy-terminal tail of GLR3.3 is essential for wound-response electrical signaling.
Title: The carboxy-terminal tail of GLR3.3 is essential for wound-response electrical signaling.
Two glutamate- and pH-regulated Ca(2+) channels are required for systemic wound signaling in Arabidopsis.
Title: Two glutamate- and pH-regulated Ca(2+) channels are required for systemic wound signaling in Arabidopsis.
Study confirms the involvement of GLR3.3 in amino acid response in A. thaliana root tip cells, supporting its role as a ligand-gated Ca2+ channel and presents the biochemical and structural characterization of its ligand-binding domain, showing that it works as an amino acid receptor with distinct specificity.
Title: The structural bases for agonist diversity in an Arabidopsis thaliana glutamate receptor-like channel.
GLR3.3 and GLR3.6 function as on switches for the propagation of wound-induced potentials beyond the wounded leaf, while GLR3.5 functions as an off switch that prevents the propagation of wound-induced electrical potentials to distal, non-neighbor leaves.
Title: New roles for the GLUTAMATE RECEPTOR-LIKE 3.3, 3.5, and 3.6 genes as on/off switches of wound-induced systemic electrical signals.
GLR3.3 is a key component of resistance against Hyaloperonospora arabidopsidis
Title: Involvement of the glutamate receptor AtGLR3.3 in plant defense signaling and resistance to Hyaloperonospora arabidopsidis.
AtGLR3.3 is required for glutathione-mediated innate immunity response in Arabidopsis Leaf.
Title: Glutamate receptor-like channel3.3 is involved in mediating glutathione-triggered cytosolic calcium transients, transcriptional changes, and innate immunity responses in Arabidopsis.
Data indicate that in roots, GLR3.4 and GLR3.2 were present primarily in the phloem, especially in the vicinity of the sieve plates, and GLR3.3 was expressed in most cells of the growing primary root but was not enriched in the phloem.
Title: Interacting glutamate receptor-like proteins in Phloem regulate lateral root initiation in Arabidopsis.
The effect of 6 amino acids on the glutamate receptors of A. thaliana, and the role of GLR3.3 and GLR3.4 in the channel mechanisms are reported.
Title: Glutamate receptor subtypes evidenced by differences in desensitization and dependence on the GLR3.3 and GLR3.4 genes.
Six amino acids commonly present in soils as well as the tripeptide glutathione were found to be strong agonists of GLR3.3-mediated calcium metabolism.
Title: Calcium entry mediated by GLR3.3, an Arabidopsis glutamate receptor with a broad agonist profile.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001333200.1

Supported by ESTs:

NM_001333201.1

Supported by ESTs:

NM_001333202.1

Supported by ESTs:

NM_103438.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate-gated calcium ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables intracellularly ligand-gated monoatomic ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in induced systemic resistance, jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to light stimulus	NAS Non-traceable Author Statement more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutamate receptor 3.3

NP_174978.1

glutamate receptor 3.3 (GLR3.3); FUNCTIONS IN: intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), GPCR, family 3, gamma-aminobutyric acid receptor, type B (InterPro:IPR002455), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 3.6 (TAIR:AT3G51480.1); Has 6567 Blast hits to 6430 proteins in 489 species: Archae - 28; Bacteria - 758; Metazoa - 4571; Fungi - 0; Plants - 644; Viruses - 2; Other Eukaryotes - 564 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

15973054..15976813

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_103438.3 → NP_174978.1 glutamate receptor 3.3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174978.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C8E7

UniProtKB/TrEMBL

A0A178WQC7, A0A654EHE2, Q6S743

Conserved Domains (2) summary

cd13686
Location:464 → 807

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:30 → 423

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
NM_001333202.1 → NP_001322170.1 glutamate receptor 3.3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C8E7

UniProtKB/TrEMBL

A0A178WQC7, A0A654EHE2, Q6S743

Conserved Domains (2) summary

cd13686
Location:464 → 807

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:30 → 423

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
NM_001333200.1 → NP_001322169.1 glutamate receptor 3.3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C8E7

UniProtKB/TrEMBL

A0A178WQC7, A0A654EHE2, Q6S743

Conserved Domains (2) summary

cd13686
Location:464 → 807

GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold

cd19990
Location:30 → 423

PBP1_GABAb_receptor_plant; periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants
NM_001333201.1 → NP_001322171.1 glutamate receptor 3.3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AT56