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    IP5PII myo-inositol polyphosphate 5-phosphatase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827526, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IP5PII
    Official Full Name
    myo-inositol polyphosphate 5-phosphatase 2
    Primary source
    TAIR:AT4G18010
    Locus tag
    AT4G18010
    See related
    Araport:AT4G18010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4; 5)P3 5-PHOSPHATASE II; 5PTASE2; AT5PTASE2; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE II; INOSITOL(1; myo-inositol polyphosphate 5-phosphatase 2; T6K21.190; T6K21_190
    Summary
    Encodes an inositol polyphosphate 5-phosphatase that appears to have Type I activity. It can dephosphorylate IP3(inositol(1,4,5)P3) and IP4 (inositol(1,3,4,5)P4), but it does not appear to be active against phosphatidylinositol 4,5 bisphosphate. Overexpression of this gene renders plants insensitive to ABA in germination and growth assays.
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    Genomic context

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    See IP5PII in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (9990988..9994524, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene NAC domain containing protein 71 Neighboring gene uncharacterized protein Neighboring gene CheY-like two-component responsive regulator family protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol polyphosphate 5-phosphatases 1 and 2 are required for regulating seedling growth. Gunesekera B, et al. Plant Physiol, 2007 Mar. PMID 17237190, Free PMC Article
    2. Arabidopsis PLC1 is required for secondary responses to abscisic acid signals. Sanchez JP, et al. Plant Cell, 2001 May. PMID 11340187, Free PMC Article
    3. Inositol polyphosphate phosphatidylinositol 5-phosphatase9 (At5ptase9) controls plant salt tolerance by regulating endocytosis. Golani Y, et al. Mol Plant, 2013 Nov. PMID 23658066
    4. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341251.1
    NM_117911.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol trisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seedling development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myo-inositol polyphosphate 5-phosphatase 2
    NP_001319979.1
    • INOSITOL(1,4,5)P3 5-PHOSPHATASE II (IP5PII); CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: DNAse I-like superfamily protein (TAIR:AT1G71710.2); Has 2627 Blast hits to 2054 proteins in 224 species: Archae - 0; Bacteria - 0; Metazoa - 957; Fungi - 640; Plants - 718; Viruses - 0; Other Eukaryotes - 312 (source: NCBI BLink).
    NP_567547.1
    • myo-inositol polyphosphate 5-phosphatase 2 (5PTASE2); CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: DNAse I-like superfamily protein (TAIR:AT1G71710.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9990988..9994524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341251.1 → NP_001319979.1  myo-inositol polyphosphate 5-phosphatase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UW61, A0A2H1ZEM5, A0A5S9XUC4

    2. NM_117911.4 → NP_567547.1  myo-inositol polyphosphate 5-phosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49700, Q9FUR2, Q9SNF1, Q9ZSC3
      UniProtKB/TrEMBL
      A0A178UW61, A0A5S9XUC4
      Conserved Domains (1) summary
      PLN03191
      Location:1 → 646
      PLN03191; Type I inositol-1,4,5-trisphosphate 5-phosphatase 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FUR2.2

    Gene LinkOut

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