AT-HF HIS HF [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: AT-HF
Official Full Name: HIS HF
Primary source: TAIR:AT4G26900
Locus tag: AT4G26900
See related: Araport:AT4G26900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: HIS HF; HISN4
Summary: encodes a glutamine amidotransferase and cyclase, catalyzes the fifth and sixth steps of the histidine biosynthetic pathway
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_118824.4

Function	Evidence Code	Pubs
enables glutaminase activity	IEA Inferred from Electronic Annotation more info
enables imidazoleglycerol-phosphate synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables oxo-acid-lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-histidine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

NP_194420.1

HIS HF (AT-HF); FUNCTIONS IN: imidazoleglycerol-phosphate synthase activity; INVOLVED IN: histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Imidazole glycerol phosphate synthase, subunit H (InterPro:IPR010139), Aldolase-type TIM barrel (InterPro:IPR013785), Glutamine amidotransferase class-I, C-terminal (InterPro:IPR000991), Ribulose-phosphate binding barrel (InterPro:IPR011060), Histidine biosynthesis, HisF (InterPro:IPR004651), Glutamine amidotransferase type 1 (InterPro:IPR017926), Histidine biosynthesis (InterPro:IPR006062), Imidazole glycerol phosphate synthase HisHF (InterPro:IPR014640); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).